Document Detail


Action of a pyrimido-pyrimidine compound on platelet behaviour in vitro.
MedLine Citation:
PMID:  5771580     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A pyrimido-pyrimidine compound (RA433) was found in vitro to be a significantly more potent inhibitor of platelet behaviour than the previously available pyrimido-pyrimidine compound RA8-dipyridamole. In a turbidimetric system RA433 inhibits platelet aggregation induced by adenosine diphosphate, collagen, and noradrenaline; further, in a glass-bead-column technique it is a powerful inhiitor of platelet adhesiveness.
Authors:
C D Forbes; G P McNicol; A S Douglas
Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  British medical journal     Volume:  2     ISSN:  0007-1447     ISO Abbreviation:  Br Med J     Publication Date:  1969 May 
Date Detail:
Created Date:  1969-07-06     Completed Date:  1969-07-06     Revised Date:  2010-10-26    
Medline Journal Info:
Nlm Unique ID:  0372673     Medline TA:  Br Med J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  483-5     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adenine Nucleotides
Blood Coagulation / drug effects
Blood Platelets / drug effects*
Collagen
Depression, Chemical
Dipyridamole / pharmacology
Humans
Morpholines / pharmacology*
Norepinephrine
Pyrimidines / pharmacology*
Chemical
Reg. No./Substance:
0/Adenine Nucleotides; 0/Morpholines; 0/Pyrimidines; 51-41-2/Norepinephrine; 58-32-2/Dipyridamole; 9007-34-5/Collagen
Comments/Corrections

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