Document Detail

Action potential characteristics in the sinus venosa of patients with and without atrial flutter.
MedLine Citation:
PMID:  19246809     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: A functional line of conduction block is often observed in the sinus venosa (SV) during typical atrial flutter (AFL). Little information, however, is available as to the action potential characteristics in the SV with respect to the functional block. METHODS AND RESULTS: Monophasic action potentials (MAPs) from the SV and lateral wall of the right atrium were recorded in 7 patients with paroxysmal AFL and 11 control patients. For both the control and AFL patients, the MAP duration at 90% repolarization (MAPD90) in the SV was longer, and the MAPD90 restitution slope was less steep than in the lateral wall. The MAPD90 in the SV in the AFL patients was slightly longer than that in the controls at the shortest cycle length (CL) tested (300 ms). However, the MAPD90s at longer CLs (350-700 ms), as well as the MAPD90 restitution slopes in the SV were comparable between the 2 groups. CONCLUSIONS: The MAPs in the SV are characterized by a long duration and flat restitution kinetics in humans. MAP properties to facilitate the development of conduction block in the SV are not appreciable in patients with paroxysmal typical AFL.
Masahide Harada; Toshiyuki Osaka; Eriko Yokoyama; Yoshio Takemoto; Atsushi Ito; Itsuo Kodama
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Publication Detail:
Type:  Journal Article     Date:  2009-02-27
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  73     ISSN:  1346-9843     ISO Abbreviation:  Circ. J.     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-03-25     Completed Date:  2009-06-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  647-53     Citation Subset:  IM    
Division of Arrhythmia and Electrophysiology, Shizuoka Saiseikai General Hospital, Shizuoka, Japan.
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MeSH Terms
Action Potentials*
Atrial Flutter / physiopathology*
Heart Atria / physiopathology
Middle Aged

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