Document Detail

Action of norepinephrine on microcirculation and PO2 distribution in the isolated perfused rat liver.
MedLine Citation:
PMID:  618779     Owner:  NLM     Status:  MEDLINE    
The addition of a potent vasoconstrictor, such as norepinephrine, induces an influx of sodium and an efflux of calcium and potassium in the parenchymal cells of the perfused liver. This reaction can be reversed by the addition of dihydroergotoxine mesylate (active substance of Hydergine). The example shows clearly that very distinct biological signals are generated under such conditions at the membrane level of the hepatocytes and presumably of other cells of liver tissue. At present, our investigations cannot clearly answer the question of whether or not swelling the shrinkage of parenchymal cells and of endothelial cells can serve as an additional mechanism for regulating microcirculation.
M Kessler; J Höper; S Ji
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gerontology     Volume:  24 Suppl 1     ISSN:  0304-324X     ISO Abbreviation:  Gerontology     Publication Date:  1978  
Date Detail:
Created Date:  1978-02-23     Completed Date:  1978-02-23     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7601655     Medline TA:  Gerontology     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  55-65     Citation Subset:  IM    
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MeSH Terms
Dihydroergotoxine / pharmacology
Electrolytes / metabolism
Liver / metabolism
Liver Circulation / drug effects*
Microcirculation / drug effects
Norepinephrine / antagonists & inhibitors,  pharmacology*
Oxygen / blood
Oxygen Consumption*
Reg. No./Substance:
0/Electrolytes; 11032-41-0/Dihydroergotoxine; 51-41-2/Norepinephrine; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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