| Action of carbamoylating agents on the uptake of metabolites in hepatomas and liver. | |
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MedLine Citation:
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PMID: 3632705 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of 2-chloroethylisocyanate, ethylisocyanate and sodium cyanate on the uptake of isotope-labeled thymidine, leucine and H2O were compared in rat liver and hepatomas. The data suggested that carbamoylating agents may have a common property of inhibiting uptake of compounds in hepatomas under conditions in which there is a smaller effect or no action in the liver of tumor-bearing rats. The distinction between tissues may have been mediated, in part, through effects on tumor circulation and was less apparent when isolated cells were studied in vitro. Preferential inhibitory effects of carbamoylating agents on the uptake of leucine and H2O were also observed with a murine hepatoma, but they were not as great as with rat hepatomas. |
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Authors:
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M A Lea; A Luke; J J Hu; O Velazquez |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Biochemical pharmacology Volume: 36 ISSN: 0006-2952 ISO Abbreviation: Biochem. Pharmacol. Publication Date: 1987 Sep |
Date Detail:
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Created Date: 1987-09-30 Completed Date: 1987-09-30 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0101032 Medline TA: Biochem Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 2775-81 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Transport / drug effects Cyanates / pharmacology* Isocyanates* Leucine / metabolism Liver / metabolism* Liver Neoplasms, Experimental / metabolism* Mice Mice, Inbred C3H Mice, Inbred C57BL Rats Rats, Inbred BUF Thymidine / metabolism Water / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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CA-35315/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cyanates; 0/Isocyanates; 109-90-0/ethyl isocyanate; 1943-83-5/2-chloroethyl isocyanate; 50-89-5/Thymidine; 61-90-5/Leucine; 7732-18-5/Water; 917-61-3/sodium cyanate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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