| Action of calycanthine on nervous transmission in cockroach central nervous system. | |
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MedLine Citation:
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PMID: 1653964 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Calycanthine, the principal alkaloid of the order Calycanthaceae, has been isolated from a species of the genus Psychotria (Rubiaceae) occurring in some Pacific islands. The drug is considered as a very powerful convulsant poison but very little is known about its mechanism of action. The symptoms observed were similar to those of some neuropoisons such as strychnine. The properties of this alkaloid have been investigated on the genesis, conduction, and transmission of the nerve impulse, using giant axons of the cockroach (Periplaneta americana). Calycanthine hydrochloride (10(-5) M), which did not alter nervous conduction in pre- and post-synaptic fibers, significantly reduced the efficacy of the synaptic transmission. |
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Authors:
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Y Adjibadé; B Hue; M Pelhate; R Anton |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Planta medica Volume: 57 ISSN: 0032-0943 ISO Abbreviation: Planta Med. Publication Date: 1991 Apr |
Date Detail:
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Created Date: 1991-10-16 Completed Date: 1991-10-16 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0066751 Medline TA: Planta Med Country: GERMANY |
Other Details:
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Languages: eng Pagination: 99-101 Citation Subset: IM |
Affiliation:
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Laboratoire de Pharmacognosie, Faculté de Pharmacie, Université Louis Pasteur, Strasbourg, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Action Potentials
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drug effects Alkaloids / isolation & purification, toxicity* Animals Axons / drug effects Central Nervous System / drug effects* Convulsants / isolation & purification, toxicity* Male Naphthyridines / toxicity* Periplaneta Plants / analysis Synapses / drug effects Synaptic Transmission / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Alkaloids; 0/Convulsants; 0/Naphthyridines; 595-05-1/calycanthine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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