Document Detail


Action of bradykinin at the cyclooxygenase step in prostanoid synthesis through the arachidonic acid cascade.
MedLine Citation:
PMID:  1810149     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Bradykinin enhances prostanoid synthesis in aorta smooth muscle cells. Free arachidonic acid also enhances prostanoid synthesis and bradykinin, unlike fatty acid releasing agents, has a synergistic effect with free arachidonic acid. Bradykinin promotes metabolite release from cells prelabeled with [14C]-arachidonic acid and this effect is blocked completely by indomethacin. High performance liquid chromatography shows increase amounts of labeled 6-keto-prostaglandin F1 alpha, prostaglandin E2 and three additional cyclooxygenase-dependent metabolites but no increase in free arachidonic acid or other metabolites either in the absence or presence of indomethacin. Fatty acid releasing agents such as A23187 and cyclosporine A have very different effects on cells. These agents enhance levels of prostanoids, a number of other cyclooxygenase-independent metabolites, and free arachidonic acid which is even more elevated with added indomethacin. Bradykinin behaves in all respects like another agent, bacterial lipopolysaccharide, and the action of both agents is consistent with a mechanism involving cyclooxygenase rather than fatty release in the arachidonic acid cascade.
Authors:
H Zhang; T S Gaginella; X Chen; D G Cornwell
Related Documents :
16732469 - Effects of arachidonic acid on the lysosomal ion permeability and osmotic stability.
21892559 - Molecular mechanisms of steatosis in nonalcoholic fatty liver disease.
6771259 - 15-hydroxy-5,8,11,13-eicosatetraenoic acid: a potent and selective inhibitor of platele...
12575899 - Lipoxygenase and cyclooxygenase metabolism: new insights in treatment and chemopreventi...
6187199 - Leukotrienes and lipoxygenase factors: mediators and modulators of the allergic reaction.
6092359 - Stereochemistry, total synthesis, and biological activity of 14,15-dihydroxy-5,8,10,12-...
13959619 - Tryptophanase-tryptophan synthetase systems in escherichia coli. ii. effect of glucose.
3385809 - Determination of deoxymononucleotides and deoxynucleosides as a tool for toxicological ...
130909 - Organization of ground substance proteoglycans in normal and osteoarthritic knee cartil...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Agents and actions     Volume:  34     ISSN:  0065-4299     ISO Abbreviation:  Agents Actions     Publication Date:  1991 Nov 
Date Detail:
Created Date:  1992-05-27     Completed Date:  1992-05-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0213341     Medline TA:  Agents Actions     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  397-404     Citation Subset:  IM    
Affiliation:
University Hospital, Vancouver, B.C., Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
6-Ketoprostaglandin F1 alpha / biosynthesis
Animals
Aorta
Arachidonic Acid / metabolism*,  pharmacology
Bradykinin / pharmacology*
Calcimycin / pharmacology
Cells, Cultured
Chromatography, High Pressure Liquid
Cyclosporine / pharmacology
Dinoprostone / biosynthesis
Drug Synergism
Guinea Pigs
Indomethacin / pharmacology
Muscle, Smooth, Vascular / drug effects,  metabolism*
Prostaglandin-Endoperoxide Synthases / metabolism*
Prostaglandins / biosynthesis*
Chemical
Reg. No./Substance:
0/Prostaglandins; 363-24-6/Dinoprostone; 506-32-1/Arachidonic Acid; 52665-69-7/Calcimycin; 53-86-1/Indomethacin; 58-82-2/Bradykinin; 58962-34-8/6-Ketoprostaglandin F1 alpha; 59865-13-3/Cyclosporine; EC 1.14.99.1/Prostaglandin-Endoperoxide Synthases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Pharmacokinetics of the enantiomers of ibuprofen in the rabbit.
Next Document:  Effects of copper depletion and D-penicillamine treatment on the ocular inflammatory response.