Document Detail

Action of bradykinin at the cyclooxygenase step in prostanoid synthesis through the arachidonic acid cascade.
MedLine Citation:
PMID:  1810149     Owner:  NLM     Status:  MEDLINE    
Bradykinin enhances prostanoid synthesis in aorta smooth muscle cells. Free arachidonic acid also enhances prostanoid synthesis and bradykinin, unlike fatty acid releasing agents, has a synergistic effect with free arachidonic acid. Bradykinin promotes metabolite release from cells prelabeled with [14C]-arachidonic acid and this effect is blocked completely by indomethacin. High performance liquid chromatography shows increase amounts of labeled 6-keto-prostaglandin F1 alpha, prostaglandin E2 and three additional cyclooxygenase-dependent metabolites but no increase in free arachidonic acid or other metabolites either in the absence or presence of indomethacin. Fatty acid releasing agents such as A23187 and cyclosporine A have very different effects on cells. These agents enhance levels of prostanoids, a number of other cyclooxygenase-independent metabolites, and free arachidonic acid which is even more elevated with added indomethacin. Bradykinin behaves in all respects like another agent, bacterial lipopolysaccharide, and the action of both agents is consistent with a mechanism involving cyclooxygenase rather than fatty release in the arachidonic acid cascade.
H Zhang; T S Gaginella; X Chen; D G Cornwell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Agents and actions     Volume:  34     ISSN:  0065-4299     ISO Abbreviation:  Agents Actions     Publication Date:  1991 Nov 
Date Detail:
Created Date:  1992-05-27     Completed Date:  1992-05-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0213341     Medline TA:  Agents Actions     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  397-404     Citation Subset:  IM    
University Hospital, Vancouver, B.C., Canada.
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MeSH Terms
6-Ketoprostaglandin F1 alpha / biosynthesis
Arachidonic Acid / metabolism*,  pharmacology
Bradykinin / pharmacology*
Calcimycin / pharmacology
Cells, Cultured
Chromatography, High Pressure Liquid
Cyclosporine / pharmacology
Dinoprostone / biosynthesis
Drug Synergism
Guinea Pigs
Indomethacin / pharmacology
Muscle, Smooth, Vascular / drug effects,  metabolism*
Prostaglandin-Endoperoxide Synthases / metabolism*
Prostaglandins / biosynthesis*
Reg. No./Substance:
0/Prostaglandins; 363-24-6/Dinoprostone; 506-32-1/Arachidonic Acid; 52665-69-7/Calcimycin; 53-86-1/Indomethacin; 58-82-2/Bradykinin; 58962-34-8/6-Ketoprostaglandin F1 alpha; 59865-13-3/Cyclosporine; EC Synthases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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