| Action of bradykinin at the cyclooxygenase step in prostanoid synthesis through the arachidonic acid cascade. | |
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MedLine Citation:
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PMID: 1810149 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Bradykinin enhances prostanoid synthesis in aorta smooth muscle cells. Free arachidonic acid also enhances prostanoid synthesis and bradykinin, unlike fatty acid releasing agents, has a synergistic effect with free arachidonic acid. Bradykinin promotes metabolite release from cells prelabeled with [14C]-arachidonic acid and this effect is blocked completely by indomethacin. High performance liquid chromatography shows increase amounts of labeled 6-keto-prostaglandin F1 alpha, prostaglandin E2 and three additional cyclooxygenase-dependent metabolites but no increase in free arachidonic acid or other metabolites either in the absence or presence of indomethacin. Fatty acid releasing agents such as A23187 and cyclosporine A have very different effects on cells. These agents enhance levels of prostanoids, a number of other cyclooxygenase-independent metabolites, and free arachidonic acid which is even more elevated with added indomethacin. Bradykinin behaves in all respects like another agent, bacterial lipopolysaccharide, and the action of both agents is consistent with a mechanism involving cyclooxygenase rather than fatty release in the arachidonic acid cascade. |
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Authors:
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H Zhang; T S Gaginella; X Chen; D G Cornwell |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Agents and actions Volume: 34 ISSN: 0065-4299 ISO Abbreviation: Agents Actions Publication Date: 1991 Nov |
Date Detail:
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Created Date: 1992-05-27 Completed Date: 1992-05-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0213341 Medline TA: Agents Actions Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 397-404 Citation Subset: IM |
Affiliation:
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University Hospital, Vancouver, B.C., Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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6-Ketoprostaglandin F1 alpha
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biosynthesis Animals Aorta Arachidonic Acid / metabolism*, pharmacology Bradykinin / pharmacology* Calcimycin / pharmacology Cells, Cultured Chromatography, High Pressure Liquid Cyclosporine / pharmacology Dinoprostone / biosynthesis Drug Synergism Guinea Pigs Indomethacin / pharmacology Muscle, Smooth, Vascular / drug effects, metabolism* Prostaglandin-Endoperoxide Synthases / metabolism* Prostaglandins / biosynthesis* |
| Chemical | |
Reg. No./Substance:
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0/Prostaglandins; 363-24-6/Dinoprostone; 506-32-1/Arachidonic Acid; 52665-69-7/Calcimycin; 53-86-1/Indomethacin; 58-82-2/Bradykinin; 58962-34-8/6-Ketoprostaglandin F1 alpha; 59865-13-3/Cyclosporine; EC 1.14.99.1/Prostaglandin-Endoperoxide Synthases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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