Document Detail


Action of almitrine on the pulmonary vasculature in ferrets and rats.
MedLine Citation:
PMID:  6652258     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The action of almitrine on pulmonary vessels was studied under constant ventilation during normoxia and hypoxia. We used ferrets, in which one lobe of lung was perfused with venous blood at constant flow rate in vivo and isolated lungs perfused with blood at constant flow in both ferrets and normal and chronically hypoxic (three weeks in 10% O2) rats. Almitrine caused constriction of the relaxed vessels of normoxic lung. During hypoxic pulmonary vasoconstriction, when pulmonary artery pressure (Ppa) was raised, almitrine had a dual action; it caused further constriction followed by dilatation over a wide dose range (0.7-118 micrograms X kg-1 in ferrets). Similar effects were seen in normal and chronically hypoxic rats; the latter have narrowed muscularized arterioles like patients with chronic obstructive airways disease. Almitrine caused a larger rise in Ppa in normoxic than hypoxic rat lungs (7.9 instead of 1.7 mmHg; p less than 0.001) and dilatation followed constriction in the latter. Verapamil reduced both the constrictor action of almitrine and hypoxic vasoconstriction and there was a strong correlation between the effect of the two stimuli before and after verapamil (r = 0.9). Attempts to identify a substance which might cause the dilator action of almitrine were unsuccessful.
Authors:
D Bee; G W Gill; C J Emery; G L Salmon; T W Evans; G R Barer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Bulletin européen de physiopathologie respiratoire     Volume:  19     ISSN:  0395-3890     ISO Abbreviation:  Bull Eur Physiopathol Respir     Publication Date:    1983 Nov-Dec
Date Detail:
Created Date:  1984-02-22     Completed Date:  1984-02-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7605263     Medline TA:  Bull Eur Physiopathol Respir     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  539-45     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Almitrine
Animals
Anoxia / drug therapy
Dose-Response Relationship, Drug
Female
Ferrets
Lung / drug effects
Male
Perfusion
Piperazines / pharmacology*
Pulmonary Circulation / drug effects
Pulmonary Veins / drug effects*
Pulmonary Wedge Pressure
Rats
Rats, Inbred Strains
Vasoconstriction / drug effects*
Chemical
Reg. No./Substance:
0/Piperazines; 27469-53-0/Almitrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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