| Action profile of the antiobesity drug candidate oleoyl-estrone in rats. | |
| | |
MedLine Citation:
|
PMID: 20339368 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Oleoyl-estrone (OE) has been presented as a potential antiobesity therapeutic, but the published series of studies from one laboratory has not yet been independently confirmed, and the exact mechanism of action is unknown. Based on the hypothesis that OE has potential for the treatment of obesity, male and female rats were chronically treated with several doses of OE to evaluate the impact of this compound on energy metabolism. Body weight, body composition, energy balance parameters and the expression of hypothalamic neuropeptides regulating food intake as well as key markers of the reproductive system were examined. OE impressively reduced food consumption and body weight gain in both sexes. Although a major part of the loss in body weight could be explained by decreased fat mass, a substantial loss of lean mass also occurred after OE administration. The loss of weight can be sufficiently explained by the suppression of food consumption, as there were no major changes in energy expenditure, locomotor activity or respiratory quotient. In situ hybridization data showed no significant change in the expression of key neuropeptides and hormone receptors regulating feeding behavior after OE treatment. Cocaine-amphetamine-regulated transcript (CART) mRNA levels were decreased in the arcuate nucleus of OE-treated rats. Hypogonadism and low plasma testosterone levels were found in OE-treated males, whereas females showed substantially increased liver size. The present data suggest that OE decreases food intake and body weight but also appears to cause a significant impact on the hypothalamus-pituitary-reproductive axis. |
| | |
Authors:
|
Sabine Strassburg; Paul T Pfluger; Nilika Chaudhary; Patrick Tso; Matthias H Tschöp; Stefan D Anker; Ruben Nogueiras; Diego Perez-Tilve |
Related Documents
:
|
19338028 - The effect of attentional training on body dissatisfaction and dietary restriction. 3203978 - Measurement of growth rates: the effect of sampling time on weight in a seabird. 16232138 - Food and water consumption in assessment of acute oral toxicity of hepalip forte in rats. 17605138 - Social norms, ideal body weight and food attitudes. 174808 - Generation and compensation of the cancer cachectic process by spontaneous modification... 12737858 - Dietary fibre in food and protection against colorectal cancer in the european prospect... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-03-25 |
Journal Detail:
|
Title: Obesity (Silver Spring, Md.) Volume: 18 ISSN: 1930-739X ISO Abbreviation: Obesity (Silver Spring) Publication Date: 2010 Dec |
Date Detail:
|
Created Date: 2010-11-24 Completed Date: 2011-06-07 Revised Date: 2012-08-13 |
Medline Journal Info:
|
Nlm Unique ID: 101264860 Medline TA: Obesity (Silver Spring) Country: United States |
Other Details:
|
Languages: eng Pagination: 2260-7 Citation Subset: IM |
Affiliation:
|
Obesity Research Center, Department of Internal Medicine, University of Cincinnati-Metabolic Diseases Institute, Cincinnati, Ohio, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adipose Tissue
/
drug effects Animals Anti-Obesity Agents / pharmacology*, therapeutic use Arcuate Nucleus / drug effects, metabolism Body Fluid Compartments / drug effects Energy Intake / drug effects* Estrone / analogs & derivatives*, pharmacology, therapeutic use Female Hypogonadism / chemically induced Hypothalamo-Hypophyseal System / drug effects In Situ Hybridization Liver / drug effects, pathology Male Nerve Tissue Proteins / genetics, metabolism Obesity / drug therapy, metabolism*, pathology Oleic Acids / pharmacology*, therapeutic use Organ Size / drug effects Pituitary-Adrenal System / drug effects RNA, Messenger / metabolism Rats Rats, Sprague-Dawley Sex Factors Testosterone / blood Weight Gain / drug effects* |
| Chemical | |
Reg. No./Substance:
|
0/Anti-Obesity Agents; 0/Nerve Tissue Proteins; 0/Oleic Acids; 0/RNA, Messenger; 0/cocaine- and amphetamine-regulated transcript protein; 0/oleoyl-estrone; 53-16-7/Estrone; 58-22-0/Testosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Hyperandrogenemia in obese peripubertal girls: correlates and potential etiological determinants.
Next Document: Mifepristone reduces weight gain and improves metabolic abnormalities associated with risperidone tr...