Document Detail

Action Potential Propagation Through Tissue Lacking Gap Junctions: Application to Engrafted Cells in Myocardial Infarcts.
MedLine Citation:
PMID:  23061055     Owner:  NLM     Status:  Publisher    
Engraftment of viable, electrically functional cells into a myocardial infarct as a method for restoring functionality is currently a topic of active research interest. Cells implanted in this way can form gap junction connectivity with each other, but often do not connect well with the surrounding tissue outside the infarct. Using a bidomain computer simulation model, we find that activation of these implanted cells by outside propagating action potentials is nevertheless possible, even if no gap junction connectivity to the surrounding tissue exists at all. The mechanism by which this action potential "tunneling" process occurs involves a current path that passes through both the intracellular and extracellular spaces, and is fundamentally spatially two-dimensional in nature. The typically convex boundary of the region occupied by these cells is found to greatly enhance the tunneling process, but unfortunately also hinders the ability of the activation of these cells to terminate reentrant waves propagating around the infarct.
Niels F Otani
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Publication Detail:
Journal Detail:
Title:  Computing in cardiology     Volume:  38     ISSN:  -     ISO Abbreviation:  Comput Cardiol (2010)     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2012-10-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101562329     Medline TA:  Comput Cardiol (2010)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  25-28     Citation Subset:  -    
Cornell University, Ithaca, NY, USA.
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