| Action of 2-beta-D-ribofuranosylthiazole-4-carboxamide (tiazofurin) against untreated human ovarian cancers in the murine xenograft assay. | |
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MedLine Citation:
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PMID: 4007612 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The activity of 2-beta-D-ribofuranosylthiazole-4-carboxamide (tiazofurin) was determined in nine untreated human ovarian cancer specimens, using the murine subrenal capsule xenograft assay. Tumor cytotoxic effect was demonstrated in seven out of the nine tumors implanted. The drug was well tolerated by the test animals. Tiazofurin may prove to be an effective chemotherapeutic agent in the treatment of ovarian cancer. |
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Authors:
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J P Micha; P R Kucera; C U Preve; M A Rettenmaier; J A Stratton; P J DiSaia |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Gynecologic oncology Volume: 21 ISSN: 0090-8258 ISO Abbreviation: Gynecol. Oncol. Publication Date: 1985 Jul |
Date Detail:
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Created Date: 1985-08-02 Completed Date: 1985-08-02 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0365304 Medline TA: Gynecol Oncol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 351-5 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antineoplastic Agents / therapeutic use* Female Mice Mice, Inbred Strains Neoplasm Transplantation Ovarian Neoplasms / drug therapy* Ribavirin / analogs & derivatives, therapeutic use* Ribonucleosides / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Ribonucleosides; 36791-04-5/Ribavirin; 60084-10-8/tiazofurin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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