Document Detail


Actigraphy in patients with seasonal affective disorder and healthy control subjects treated with light therapy.
MedLine Citation:
PMID:  16102546     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Abnormalities of the circadian rest-activity cycle are hypothesized to accompany the clinical picture of seasonal affective disorder (SAD). The purpose of this study was to investigate if bright light therapy (BLT) is able to reverse these disturbances. METHODS: Seventeen SAD outpatients and 17 sex- and age-matched healthy control subjects were treated with BLT administered in the morning for 4 weeks. Activity levels were measured with wrist actigraphy. RESULTS: SAD patients had 33% lower total (p = .031) and 43% lower daylight activity (p = .006) in week 1 compared with control subjects. The relative amplitude of the sleep-wake cycle was attenuated by 6% in patients (p = .025); they were phase delayed by 55 minutes (p = .023) and had significantly lower sleep efficiency (p = .030). Total (p = .002) and daylight activity (p = .001) increased after 4 weeks of treatment in SAD patients. Moreover, BLT led to increase of relative amplitude (p = .005), advance of delayed rhythms (p = .036), and improved sleep efficiency (p = .011) in patients. Intradaily stability, measuring the strength of coupling of the rhythm to external zeitgebers, increased by 9% both in patients and healthy control subjects (p = .032). CONCLUSIONS: Treatment with BLT normalizes disturbed activity patterns and restores circadian rhythms in SAD patients. BLT might also stabilize the circadian rhythm in nondepressed individuals during the fall-winter season.
Authors:
Dietmar Winkler; Edda Pjrek; Nicole Praschak-Rieder; Matthäus Willeit; Lukas Pezawas; Anastasios Konstantinidis; Jürgen Stastny; Siegfried Kasper
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Biological psychiatry     Volume:  58     ISSN:  0006-3223     ISO Abbreviation:  Biol. Psychiatry     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-08-16     Completed Date:  2005-10-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0213264     Medline TA:  Biol Psychiatry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  331-6     Citation Subset:  IM    
Affiliation:
Department of General Psychiatry, Medical University of Vienna, Vienna, Austria. dietmar.winkler@meduniwien.ac.at
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MeSH Terms
Descriptor/Qualifier:
Activity Cycles / physiology,  radiation effects*
Adult
Analysis of Variance
Case-Control Studies
Female
Humans
Male
Middle Aged
Motor Activity / radiation effects*
Phototherapy*
Psychiatric Status Rating Scales
Seasonal Affective Disorder / therapy*
Sleep / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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