Document Detail


Act your age: tuning cell behavior to tissue requirements in interfollicular epidermis.
MedLine Citation:
PMID:  22981943     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In all tissues the balance of cell proliferation and differentiation needs to be tuned to match the varying requirements of embryonic development and adult life. This is well illustrated by the interfollicular epidermis (IFE), which undergoes expansion and remodeling in utero, significant post natal growth and is then maintained in homeostasis. In addition to sustaining a high daily turnover of cells, the epidermis is able to re-populate areas of tissue damage due to common environmental stresses such as wounding. Here recent insights into proliferating cell behavior in IFE and how this changes through development and into adulthood are discussed.
Authors:
Amit Roshan; Philip H Jones
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2012-09-07
Journal Detail:
Title:  Seminars in cell & developmental biology     Volume:  23     ISSN:  1096-3634     ISO Abbreviation:  Semin. Cell Dev. Biol.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-11-12     Completed Date:  2013-08-12     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  9607332     Medline TA:  Semin Cell Dev Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  884-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Aging*
Animals
Epidermis / cytology*,  growth & development
Humans
Stem Cells / cytology
Sweat Glands / cytology
Grant Support
ID/Acronym/Agency:
MC_U105370181//Medical Research Council

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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