| Acrylic polymeric nanospheres for the release and recognition of molecules of clinical interest. | |
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MedLine Citation:
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PMID: 15556352 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cross-linked poly(methylmethacrylate-co-methacrylic acid) nanospheres were imprinted with theophylline through template radical polymerisation in diluted acetonitrile solution. This study will focus on the effect of functional monomer nature used (methylmethacrylate and/or methacrylic acid) in the recognition and in the release of template in order to develop a material with combined properties of drug delivery and rebinding for clinical applications. After template extraction the nanospheres showed satisfactory recognition properties (up to 1mg template/g of polymer). Moreover polymers prepared selectively removed theophylline with a theophylline rebinding of 5.1 times higher than that of caffeine, a compound of similar structure. Drug release properties were also satisfactory (up to 95% of loaded theophylline in 7 days). |
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Authors:
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G Ciardelli; B Cioni; C Cristallini; N Barbani; D Silvestri; P Giusti |
Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biosensors & bioelectronics Volume: 20 ISSN: 0956-5663 ISO Abbreviation: Biosens Bioelectron Publication Date: 2004 Dec |
Date Detail:
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Created Date: 2004-11-23 Completed Date: 2005-06-03 Revised Date: 2009-07-14 |
Medline Journal Info:
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Nlm Unique ID: 9001289 Medline TA: Biosens Bioelectron Country: England |
Other Details:
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Languages: eng Pagination: 1083-90 Citation Subset: IM |
Affiliation:
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Department of Chemical Engineering, Industrial Chemistry, Materials Science, Via Diotisalvi, 2 56126 Pisa, Italy. gianluca@ing.unipi.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acrylic Resins
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chemistry Binding Sites Coated Materials, Biocompatible / chemistry* Cross-Linking Reagents / chemistry Diffusion Drug Delivery Systems / methods* Nanotubes / chemistry*, ultrastructure* Particle Size Polymethacrylic Acids / chemistry* Surface Properties Theophylline / administration & dosage, chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Acrylic Resins; 0/Coated Materials, Biocompatible; 0/Cross-Linking Reagents; 0/Polymethacrylic Acids; 25086-15-1/methylmethacrylate-methacrylic acid copolymer; 58-55-9/Theophylline; 9003-05-8/polyacrylamide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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