Document Detail


Acrylamide intake through diet and human cancer risk.
MedLine Citation:
PMID:  18624443     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
More than one-third of the calories consumed by U.S. and European populations contain acrylamide, a substance classified as a "probable human carcinogen" based on laboratory data. Thus, it is a public health concern to evaluate whether intake of acrylamide at levels found in the food supply is an important cancer risk factor. Mean dietary intake of acrylamide in adults averages 0.5 microg/kg of body weight per day, whereas intake is higher among children. Several epidemiological studies examining the relationship between dietary intake of acrylamide and cancers of the colon, rectum, kidney, bladder, and breast have been undertaken. These studies found no association between intake of specific foods containing acrylamide and risk of these cancers. Moreover, there was no relationship between estimated acrylamide intake in the diet and cancer risk. Results of this research are compared with other epidemiological studies, and the findings are examined in the context of data from animal models. The importance of epidemiological studies to establish the public health risk associated with acrylamide in food is discussed, as are the limitations and future directions of such studies.
Authors:
Lorelei A Mucci; Kathryn M Wilson
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2008-07-15
Journal Detail:
Title:  Journal of agricultural and food chemistry     Volume:  56     ISSN:  1520-5118     ISO Abbreviation:  J. Agric. Food Chem.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-08-07     Completed Date:  2008-09-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0374755     Medline TA:  J Agric Food Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  6013-9     Citation Subset:  IM    
Affiliation:
Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, Massachusetts 02115, USA. lmucci@hsph.harvard.edu
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MeSH Terms
Descriptor/Qualifier:
Acrylamide / administration & dosage*,  analysis,  toxicity*
Adult
Animals
Body Weight
Breast Neoplasms / epidemiology
Child
Colorectal Neoplasms / epidemiology
Diet*
Diet Records
Female
Food Analysis
Humans
Kidney Neoplasms / epidemiology
Male
Models, Animal
Neoplasms / chemically induced*,  epidemiology
Risk Factors
Sweden / epidemiology
Urinary Bladder Neoplasms / epidemiology
Grant Support
ID/Acronym/Agency:
R25 CA098566/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
79-06-1/Acrylamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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