| Acrylamide intake through diet and human cancer risk. | |
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MedLine Citation:
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PMID: 18624443 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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More than one-third of the calories consumed by U.S. and European populations contain acrylamide, a substance classified as a "probable human carcinogen" based on laboratory data. Thus, it is a public health concern to evaluate whether intake of acrylamide at levels found in the food supply is an important cancer risk factor. Mean dietary intake of acrylamide in adults averages 0.5 microg/kg of body weight per day, whereas intake is higher among children. Several epidemiological studies examining the relationship between dietary intake of acrylamide and cancers of the colon, rectum, kidney, bladder, and breast have been undertaken. These studies found no association between intake of specific foods containing acrylamide and risk of these cancers. Moreover, there was no relationship between estimated acrylamide intake in the diet and cancer risk. Results of this research are compared with other epidemiological studies, and the findings are examined in the context of data from animal models. The importance of epidemiological studies to establish the public health risk associated with acrylamide in food is discussed, as are the limitations and future directions of such studies. |
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Authors:
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Lorelei A Mucci; Kathryn M Wilson |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2008-07-15 |
Journal Detail:
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Title: Journal of agricultural and food chemistry Volume: 56 ISSN: 1520-5118 ISO Abbreviation: J. Agric. Food Chem. Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-08-07 Completed Date: 2008-09-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0374755 Medline TA: J Agric Food Chem Country: United States |
Other Details:
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Languages: eng Pagination: 6013-9 Citation Subset: IM |
Affiliation:
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Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, Massachusetts 02115, USA. lmucci@hsph.harvard.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acrylamide
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administration & dosage*,
analysis,
toxicity* Adult Animals Body Weight Breast Neoplasms / epidemiology Child Colorectal Neoplasms / epidemiology Diet* Diet Records Female Food Analysis Humans Kidney Neoplasms / epidemiology Male Models, Animal Neoplasms / chemically induced*, epidemiology Risk Factors Sweden / epidemiology Urinary Bladder Neoplasms / epidemiology |
| Grant Support | |
ID/Acronym/Agency:
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R25 CA098566/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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79-06-1/Acrylamide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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