Document Detail

Acrylamide induced immunosuppression in rats and its modulation by 6-MFA, an interferon inducer.
MedLine Citation:
PMID:  8077609     Owner:  NLM     Status:  MEDLINE    
In the present communication, we describe acrylamide (ACR) induced immunotoxicity and its modulation by an interferon inducer, the 6th mycelial fraction acetone (6-MFA) of Aspergillus ochraceus ATCC 28706. ACR administration to rats produced a significant decrease in the weight of spleen (p < 0.001), thymus (p < 0.001) and mesenteric lymph nodes (p < 0.05). A decrease in cellularity of spleen (p < 0.001), thymus (p < 0.001), bone marrow (p < 0.001) and circulating blood lymphocyte population (p < 0.001) was also recorded. ACR suppressed the humoral as well as cell mediated immunity as assessed by erythrocyte antibody complement (EAC)-rosettes (p < 0.001), hemagglutination titre (p < 0.001), PFC (p < 0.001) and the delayed type hypersensitivity response against sheep red blood cells (SRBC, p < 0.001). ACR treated immunosuppressed rats when treated with 6-MFA restored the circulating lymphocyte number to the normal level and a partial recovery in the weight of spleen and thymus. Potentiation of EAC-rosettes, hemagglutination titre, IgM-PFC and DTH response against SRBC was observed. It is concluded that 6-MFA ameliorate the ACR induced toxicity. This study may be of significance in prevention of ACR toxicity.
S I Zaidi; S Raisuddin; K P Singh; A Jafri; R Husain; M M Husain; S A Mall; P K Seth; P K Ray
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Immunopharmacology and immunotoxicology     Volume:  16     ISSN:  0892-3973     ISO Abbreviation:  Immunopharmacol Immunotoxicol     Publication Date:  1994 May 
Date Detail:
Created Date:  1994-10-05     Completed Date:  1994-10-05     Revised Date:  2009-05-14    
Medline Journal Info:
Nlm Unique ID:  8800150     Medline TA:  Immunopharmacol Immunotoxicol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  247-60     Citation Subset:  IM    
Preventive Toxicology Division, Industrial Toxicology Research Centre, Lucknow, India.
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MeSH Terms
Acrylamides / antagonists & inhibitors,  toxicity*
Erythrocytes / immunology
Fungal Proteins / pharmacology*
Hemolytic Plaque Technique
Hypersensitivity, Delayed / immunology
Immunity / drug effects*
Interferon Inducers / pharmacology*
Leukocyte Count / drug effects
Lymphoid Tissue / drug effects
Macrophages / drug effects
Organ Size / drug effects
Phagocytosis / drug effects
Rosette Formation
Sheep / immunology
Reg. No./Substance:
0/Acrylamides; 0/Fungal Proteins; 0/Interferon Inducers; 42615-31-6/MFA 6 extract, Aspergillus ochraceus; 79-06-1/Acrylamide

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