| Acrylamide exposure from foods of the Dutch population and an assessment of the consequent risks. | |
| | |
MedLine Citation:
|
PMID: 12963010 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
At the end of April 2002, the Swedish Food Administration reported the presence of acrylamide in heat treated food products. Acrylamide has been shown to be toxic and carcinogenic in animals, and has been classified by the WHO/IARC among others as 'probably carcinogenic for humans'. The purposes of this study were firstly to analyse acrylamide contents of the most important foods contributing to such exposure, secondly, to estimate the acrylamide exposure in a representative sample of the Dutch population, and thirdly to estimate the public health risks of this consumption. We analysed the acrylamide content of foods with an LC-MS-MS method. The results were then used to estimate the acrylamide exposure of consumers who participated in the National Food Consumption Survey (NFCS) in 1998 (n=6250). The exposure was estimated using the probabilistic approach for the total Dutch population and several age groups. For 344 food products, acrylamide amounts ranged from <30 to 3100 microg/kg. Foods with the highest mean acrylamide amounts were potato crisps (1249 microg/kg), chips (deep-fried) (351 microg/kg), cocktail snacks (1060 microg/kg), and gingerbread (890 microg/kg). The mean acrylamide exposure of the NFCS participants was 0.48 microg/kg bw/day. Risk of neurotoxicity is negligible. From exposure estimations it appears that the additional cancer risk might not be negligible. |
| | |
Authors:
|
E J M Konings; A J Baars; J D van Klaveren; M C Spanjer; P M Rensen; M Hiemstra; J A van Kooij; P W J Peters |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association Volume: 41 ISSN: 0278-6915 ISO Abbreviation: Food Chem. Toxicol. Publication Date: 2003 Nov |
Date Detail:
|
Created Date: 2003-09-09 Completed Date: 2003-11-21 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8207483 Medline TA: Food Chem Toxicol Country: England |
Other Details:
|
Languages: eng Pagination: 1569-79 Citation Subset: IM |
Affiliation:
|
The Food and Consumer Product Safety Authority/Inspectorate for Health Protection and Veterinary Public Health, Region South, PO Box 2168, 5600 CD Eindhoven, The Netherlands. erik.konings@kvw.nl |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acrylamides
/
adverse effects*,
analysis* Adolescent Adult Age Factors Aged Aged, 80 and over Carcinogens / toxicity Child Child, Preschool Chromatography, Liquid Data Collection Diet* Female Food Analysis* Health Humans Infant Male Mass Spectrometry Middle Aged Netherlands Quality Control Risk Assessment |
| Chemical | |
Reg. No./Substance:
|
0/Acrylamides; 0/Carcinogens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The protective effects of Aspergillus candidus metabolites against hydrogen peroxide-induced oxidati...
Next Document: Dietary intake of acrylamide in Sweden.