Document Detail


Acrylamide: a dietary carcinogen formed in vivo?
MedLine Citation:
PMID:  18624427     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Acrylamide, a chemical formed during heating of human foods, reacts with N-terminal valine in hemoglobin (Hb) and forms stable reaction products (adducts). These adducts to N-terminal valine in Hb have been used to estimate daily intake of acrylamide. Daily intake of acrylamide estimated from Hb adduct levels was higher than daily intake estimated from dietary questionnaires, possibly indicating other sources of exposures. Therefore, in this study the possible endogenous formation of acrylamide was investigated by treating mice with FeSO 4, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-hydrochloric acid (MPTP), or methamphetamine (METH). Acrylamide Hb adducts were determined, and a significant increase ( p < 0.05) in acrylamide Hb adduct levels was observed 24 h following treatment with FeSO 4 and 72 h following treatment with MPTP or METH. The results of this study show that acrylamide Hb adduct levels are increased in mice treated with compounds known to induce free radicals, thus suggesting the endogenous production of acrylamide.
Authors:
Eden Tareke; Beverly Lyn-Cook; Bonnie Robinson; Syed F Ali
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.     Date:  2008-07-15
Journal Detail:
Title:  Journal of agricultural and food chemistry     Volume:  56     ISSN:  1520-5118     ISO Abbreviation:  J. Agric. Food Chem.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-08-07     Completed Date:  2008-09-29     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0374755     Medline TA:  J Agric Food Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  6020-3     Citation Subset:  IM    
Affiliation:
Division of Personalized Nutrition and Medicine, Toxicologic Pathology Association, Inc., Jefferson, Arkansas 72079, USA. eden.tareke@fda.hhs.gov
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MeSH Terms
Descriptor/Qualifier:
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / pharmacology
Acrylamide / administration & dosage,  blood,  chemical synthesis*
Animals
Carcinogens / chemical synthesis*
Diet
Ferrous Compounds / pharmacology
Food Analysis*
Food Handling / methods*
Globins / chemistry,  isolation & purification
Hemoglobins / chemistry
Hot Temperature*
Male
Methamphetamine / pharmacology
Mice
Mice, Inbred C57BL
Valine / chemistry
Chemical
Reg. No./Substance:
0/Carcinogens; 0/Ferrous Compounds; 0/Hemoglobins; 28289-54-5/1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 537-46-2/Methamphetamine; 7004-03-7/Valine; 7720-78-7/ferrous sulfate; 79-06-1/Acrylamide; 9004-22-2/Globins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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