Document Detail


Acrylamide alters oxidative enzyme activity in rat motoneurons.
MedLine Citation:
PMID:  4035705     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Acrylamide (ACR) produces a central-peripheral distal axonopathy, via an unknown mechanism. We have investigated the effects of ACR on the activity of enzymes responsible for the oxidation of NADH (NADH-tetrazolium reductase activity, NADH-TR) with quantitative histochemical techniques. Chronic (5- or 10-day) injection of ACR (50 mg/kg/day) resulted in a significant decrease in enzyme activity in soleus motoneurons, which normally have high NADH-TR activity. The NADH-TR activity in motoneurons with low oxidative metabolism was not significantly affected. Retrograde labeling of motoneurons with horseradish peroxidase was diminished by the acrylamide treatment. These data demonstrate an acrylamide-induced change in the oxidative metabolism of certain motoneurons; further study will determine whether oxidative metabolism is the primary site of action of ACR in producing the distal axonopathy.
Authors:
D W Sickles; B D Goldstein
Related Documents :
3789705 - The nadp(h) redox couple in yeast metabolism.
22851015 - Comparative characterization of recombinant zz protein-alkaline phosphatase and its app...
6895515 - Purification and some properties of carbon monoxide dehydrogenase from pseudomonas carb...
24563465 - Yeast pah1p phosphatidate phosphatase is regulated by proteasome-mediated degradation.
15051835 - Uptake, hydrolysis, and metabolism of pyridoxine-5'-beta-d-glucoside in caco-2 cells.
19353425 - Sporothrix schenckii: purification and partial biochemical characterization of glucosam...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Toxicology letters     Volume:  26     ISSN:  0378-4274     ISO Abbreviation:  Toxicol. Lett.     Publication Date:  1985 Aug 
Date Detail:
Created Date:  1985-10-17     Completed Date:  1985-10-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7709027     Medline TA:  Toxicol Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  111-8     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Acrylamide
Acrylamides / pharmacology*
Animals
Histocytochemistry
Horseradish Peroxidase
Motor Neurons / drug effects*,  enzymology
NADH Tetrazolium Reductase / antagonists & inhibitors*
NADH, NADPH Oxidoreductases / antagonists & inhibitors*
Rats
Grant Support
ID/Acronym/Agency:
NS18664/NS/NINDS NIH HHS; OH 02020/OH/NIOSH CDC HHS; S-07RR05365-21/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Acrylamides; 79-06-1/Acrylamide; EC 1.11.1.-/Horseradish Peroxidase; EC 1.6.-/NADH Tetrazolium Reductase; EC 1.6.-/NADH, NADPH Oxidoreductases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Toxicology of indecainide hydrochloride after intravenous administration to rats and dogs.
Next Document:  Elevation of hepatic metallothionein in rats chronically exposed to dietary ethionine.