Document Detail


Acromegaly with Normal Insulin-Like Growth Factor-1 Levels and Congestive Heart Failure as the First Clinical Manifestation.
MedLine Citation:
PMID:  25491785     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The leading cause of morbidity and mortality in patients with acromegaly is cardiovascular complications. Myocardial exposure to excessive growth hormone can cause ventricular hypertrophy, hypertension, arrhythmia, and diastolic dysfunction. However, congestive heart failure as a result of systolic dysfunction is observed only rarely in patients with acromegaly. Most cases of acromegaly exhibit high levels of serum insulin-like growth factor-1 (IGF-1). Acromegaly with normal IGF-1 levels is rare and difficult to diagnose. Here, we report a rare case of an acromegalic patient whose first clinical manifestation was severe congestive heart failure, despite normal IGF-1 levels. We diagnosed acromegaly using a glucose-loading growth hormone suppression test. Cardiac function and myocardial hypertrophy were improved 6 months after transsphenoidal resection of a pituitary adenoma.
Authors:
Hyae Min Lee; Sun Hee Lee; In Ho Yang; In Kyoung Hwang; You Cheol Hwang; Kyu Jeung Ahn; Ho Yeon Chung; Hui Jeong Hwang; In Kyung Jeong
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-12-09
Journal Detail:
Title:  Endocrinology and metabolism (Seoul, Korea)     Volume:  -     ISSN:  2093-596X     ISO Abbreviation:  Endocrinol Metab (Seoul)     Publication Date:  2014 Dec 
Date Detail:
Created Date:  2014-12-10     Completed Date:  -     Revised Date:  2014-12-11    
Medline Journal Info:
Nlm Unique ID:  101554139     Medline TA:  Endocrinol Metab (Seoul)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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