| Acromegaly per se does not increase the risk for coronary artery disease. | |
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MedLine Citation:
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PMID: 20145047 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CONTEXT: Information about the risk and course of coronary artery disease (CAD) in acromegaly is limited. OBJECTIVE: To evaluate CAD risk in acromegalic patients at diagnosis and after successful treatment during follow-up. SUBJECTS AND METHODS: Twenty-five consecutive patients (age 45.1+/-10.6 years, 15 women) were studied at the time of diagnosis, and 19 patients were re-evaluated after 4.6+/-1.1 years. The European Society of Cardiology (ESC) risk score was calculated, and a cardiac computed tomography was performed for detection and quantification (Agatston score (AS)) of coronary artery calcium (CACs). Fifty age-, sex-, and CAD risk-matched subjects and CAC data from the population-based Heinz Nixdorf Recall (HNR) study served as controls. RESULTS: In 21 of the 25 patients, the 10-year risk of developing CAD according to the ESC risk score was low (<10%) and high (>20%) in four patients. The AS was lower than in controls (2.6+/-7.9 vs 66+/-182; P=0.014) and less patients had a positive CAC (AS>0) (20 vs 48%, P=0.024), which in the acromegalic patients was less than expected from the HNR study. The AS did not correlate with GH excess or disease duration. In 19 acromegalic patients, who were in remission and re-evaluated after 4.6+/-1.1 years, the ESC risk (P=0.102) and the AS (P=0.173) did not change significantly and no symptomatic CAD event occurred. CONCLUSION: CAD risk in newly diagnosed acromegalic patients was low and remained stable after successful treatment. CAC was lower than in controls suggesting that GH excess per se does not carry an additional CAD risk. |
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Authors:
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Hiroyoshi Akutsu; J?rgen Kreutzer; Gerald Wasmeier; Dieter Ropers; Christian Rost; Matthias M?hlig; Henri Wallaschofski; Michael Buchfelder; Christof Sch?fl |
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Publication Detail:
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Type: Journal Article Date: 2010-02-09 |
Journal Detail:
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Title: European journal of endocrinology / European Federation of Endocrine Societies Volume: 162 ISSN: 1479-683X ISO Abbreviation: Eur. J. Endocrinol. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-27 Completed Date: 2010-05-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9423848 Medline TA: Eur J Endocrinol Country: England |
Other Details:
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Languages: eng Pagination: 879-86 Citation Subset: IM |
Affiliation:
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Department of Neurosurgery, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acromegaly
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complications* Adult Calcium / metabolism Coronary Artery Disease / etiology*, radiography Coronary Vessels / metabolism Echocardiography Female Follow-Up Studies Humans Male Middle Aged Prospective Studies Risk Tomography, X-Ray Computed |
| Chemical | |
Reg. No./Substance:
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7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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