| Acromegaly and hypertension: prevalence and relationship to the renin-angiotensin-aldosterone system. | |
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MedLine Citation:
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PMID: 2198380 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The prevalence of arterial hypertension was evaluated in a retrospective study of 158 patients with acromegaly, and results were compared to control populations, namely, the Munich Blood Pressure Study (MBPS) and the Framingham Study. The prevalence of hypertension (defined according to WHO criteria) was significantly increased in female patients but not in men; hypertensive acromegalics were older and tended to have higher body weight compared to normotensive patients. Hypertension was not related to serum concentrations of growth hormone. After successful treatment of acromegaly, growth hormone levels and systolic and diastolic blood pressure fell only in female hypertensive acromegalics; this did not occur in normotensives. The rise in plasma renin activity in response to upright posture was diminished in 57.9% of acromegalic patients. The prevalence of low-renin hypertension in our group of patients was 31.6%, which is similar to figures reported for unselected non-acromegalic subjects with essential hypertension. Orthostatic renin activity was weakly and inversely related (r = -0.3) to blood pressure. No relationship between plasma aldosterone concentration and blood pressure could be detected; however, in acromegalic women, aldosterone rose higher after ambulation than in men. In conclusion, hypertension is a common problem in acromegaly and at least in part related to similar risk factors in control populations. The association with abnormalities of the renin-angiotensin-aldosterone system is difficult to interpret and does not offer an explanation for the slight increase in the prevalence of hypertension. |
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Authors:
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C Kraatz; G Benker; F Weber; D Lüdecke; H Hirche; D Reinwein |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Klinische Wochenschrift Volume: 68 ISSN: 0023-2173 ISO Abbreviation: Klin. Wochenschr. Publication Date: 1990 Jun |
Date Detail:
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Created Date: 1990-09-05 Completed Date: 1990-09-05 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 2985205R Medline TA: Klin Wochenschr Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 583-7 Citation Subset: IM |
Affiliation:
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Abteilung für klinische Endokrinologie, Universität Essen. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acromegaly
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blood,
epidemiology* Aldosterone / blood Blood Pressure / physiology Cross-Sectional Studies Female Germany, West / epidemiology Growth Hormone / blood Humans Hypertension / blood, epidemiology* Incidence Male Middle Aged Renin / blood Renin-Angiotensin System / physiology* |
| Chemical | |
Reg. No./Substance:
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52-39-1/Aldosterone; 9002-72-6/Growth Hormone; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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