Document Detail

Acromegaly and the cardiovascular system.
MedLine Citation:
PMID:  17047385     Owner:  NLM     Status:  MEDLINE    
Acromegaly is characterized by an increased cardiovascular morbidity and mortality. In fact, growth hormone and insulin-like growth factor-I excess induces a specific cardiomyopathy. The heart is involved from the very early stages of the disease in which the hyperkinetic syndrome (high heart rate and increased systolic output) takes place. Frequently, if the disease is untreated for many years or unsuccessfully treated, concentric biventricular hypertrophy and diastolic dysfunction can develop and, at least, lead to diastolic congestive heart failure. Rhythm disturbances and valve dysfunction are also frequently described in acromegaly. The coexistence of other complications, such as diabetes and arterial hypertension, can induce the worsening of acromegalic cardiomyopathy. Control of acromegaly by surgery or pharmacotherapy could improve cardiovascular morbidity thanks to decreasing left ventricular mass and reducing cardiac dysfunction. In conclusion, an early diagnosis and a careful evaluation of cardiac function, morphology and activity seem to be mandatory in acromegaly.
Gaetano Lombardi; Mariano Galdiero; Renata S Auriemma; Rosario Pivonello; Annamaria Colao
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Neuroendocrinology     Volume:  83     ISSN:  0028-3835     ISO Abbreviation:  Neuroendocrinology     Publication Date:  2006  
Date Detail:
Created Date:  2006-10-18     Completed Date:  2006-11-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0035665     Medline TA:  Neuroendocrinology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  211-7     Citation Subset:  IM    
Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Naples, Italy.
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MeSH Terms
Acromegaly / complications*,  metabolism
Arrhythmias, Cardiac / etiology,  metabolism
Cardiomyopathies / etiology*,  metabolism
Human Growth Hormone / metabolism
Hypertension / etiology,  metabolism
Pituitary Neoplasms / complications*,  metabolism
Somatomedins / metabolism
Vascular Diseases / etiology*,  metabolism
Reg. No./Substance:
0/Somatomedins; 12629-01-5/Human Growth Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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