Document Detail

Acrokeratosis paraneoplastica (Bazex syndrome) presenting in a patient with metastatic breast carcinoma: possible etiologic role of zinc.
MedLine Citation:
PMID:  17374318     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Bazex syndrome (acrokeratosis paraneoplastica) is a rare paraneoplastic syndrome that usually occurs in males over 40 years old and is particularly associated with squamous cell carcinoma of the upper aerodigestive tract and adenopathy above the diaphragm. OBJECTIVE: The objectives of our article are (1) to describe a unique case of acrokeratosis paraneoplastica and (2) to review the current literature regarding skin findings, commonly associated neoplasms, and treatment options relative to this condition. PATIENT: We describe a 68-year-old female with lobular breast carcinoma, complicated by local and distant recurrences, who presented with a 1-year history of prominent acral skin and nail changes. RESULTS: Our patient's clinical skin findings improved significantly following treatment and partial remission of her underlying malignancy. CONCLUSIONS: Our patient represents one of few females described with this syndrome, which is especially rare in association with lobular breast carcinoma. Further, the patient's presentation is unique as she was discovered to demonstrate laboratory findings consistent with coexistent porphyria cutanea tarda and relative zinc deficiency.
Muba Taher; Parbeer Grewal; Beth Gunn; Katia Tonkin; Gilles Lauzon
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of cutaneous medicine and surgery     Volume:  11     ISSN:  1203-4754     ISO Abbreviation:  J Cutan Med Surg     Publication Date:    2007 Mar-Apr
Date Detail:
Created Date:  2007-03-21     Completed Date:  2007-07-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9614685     Medline TA:  J Cutan Med Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  78-83     Citation Subset:  IM    
Division of Dermatology, Department of Obstetrics and Gynecology, University of Alberta, Edmonton, AB, Canada.
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MeSH Terms
Breast Neoplasms / complications*,  pathology
Carcinoma, Lobular / complications*,  pathology
Diagnosis, Differential
Nail Diseases / etiology
Neoplasm Metastasis
Paraneoplastic Syndromes / diagnosis,  etiology
Porphyria Cutanea Tarda / complications
Zinc / blood,  deficiency
Reg. No./Substance:

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