| Acrokeratosis paraneoplastica (Bazex syndrome) presenting in a patient with metastatic breast carcinoma: possible etiologic role of zinc. | |
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MedLine Citation:
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PMID: 17374318 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Bazex syndrome (acrokeratosis paraneoplastica) is a rare paraneoplastic syndrome that usually occurs in males over 40 years old and is particularly associated with squamous cell carcinoma of the upper aerodigestive tract and adenopathy above the diaphragm. OBJECTIVE: The objectives of our article are (1) to describe a unique case of acrokeratosis paraneoplastica and (2) to review the current literature regarding skin findings, commonly associated neoplasms, and treatment options relative to this condition. PATIENT: We describe a 68-year-old female with lobular breast carcinoma, complicated by local and distant recurrences, who presented with a 1-year history of prominent acral skin and nail changes. RESULTS: Our patient's clinical skin findings improved significantly following treatment and partial remission of her underlying malignancy. CONCLUSIONS: Our patient represents one of few females described with this syndrome, which is especially rare in association with lobular breast carcinoma. Further, the patient's presentation is unique as she was discovered to demonstrate laboratory findings consistent with coexistent porphyria cutanea tarda and relative zinc deficiency. |
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Authors:
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Muba Taher; Parbeer Grewal; Beth Gunn; Katia Tonkin; Gilles Lauzon |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of cutaneous medicine and surgery Volume: 11 ISSN: 1203-4754 ISO Abbreviation: J Cutan Med Surg Publication Date: 2007 Mar-Apr |
Date Detail:
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Created Date: 2007-03-21 Completed Date: 2007-07-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9614685 Medline TA: J Cutan Med Surg Country: United States |
Other Details:
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Languages: eng Pagination: 78-83 Citation Subset: IM |
Affiliation:
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Division of Dermatology, Department of Obstetrics and Gynecology, University of Alberta, Edmonton, AB, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Breast Neoplasms / complications*, pathology Carcinoma, Lobular / complications*, pathology Diagnosis, Differential Female Humans Keratosis Nail Diseases / etiology Neoplasm Metastasis Paraneoplastic Syndromes / diagnosis, etiology Porphyria Cutanea Tarda / complications Syndrome Zinc / blood, deficiency |
| Chemical | |
Reg. No./Substance:
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7440-66-6/Zinc |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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