Document Detail

Acral pseudolymphomatous angiokeratoma of children in an elderly man: report of a case and review of the literature.
MedLine Citation:
PMID:  20465644     Owner:  NLM     Status:  MEDLINE    
Acral pseudolymphomatous angiokeratoma of children (APACHE) is clinically characterized by angiomatous papules that preferentially affect acral areas of children. It is currently believed to be a variant of pseudolymphoma rather than angiokeratoma. Histopathologically, a mixed inflammatory cell infiltrate comprising B- and T-lymphocytes and a proliferation of thick-walled blood vessels are the hallmark. In the literature, although more adult cases are being described, the clinical, epidemiologic and histopathologic data of this presentation is scant. We report a 76-year-old man who presented with a 5-year history of progressively increasing asymptomatic dusky dome-shaped papules and plaques on his upper and lower extremities. Histology was consistent with APACHE. After reviewing all the adult cases in the literature and comparing them to the classical variant in children, we found no significant difference warranting separating these two variants. We prefer the designation "papular angiolymphoid hyperplasia" to APACHE as it encompasses all the childhood and adult cases involving acral and nonacral sites and highlights the histological and sometimes clinical similarities this entity shares with angiolymphoid hyperplasia with eosinophilia.
Adele Chedraoui; Joelle Malek; Hussam Tamraz; Shukrallah Zaynoun; Abdul Ghani Kibbi; Samer Ghosn
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  International journal of dermatology     Volume:  49     ISSN:  1365-4632     ISO Abbreviation:  Int. J. Dermatol.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-05-14     Completed Date:  2010-08-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0243704     Medline TA:  Int J Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  184-8     Citation Subset:  IM    
Department of Dermatology, American University of Beirut Medical Center, Beirut, Lebanon.
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MeSH Terms
Angiokeratoma / diagnosis,  pathology*
Biopsy, Needle
Follow-Up Studies
Physical Examination
Pseudolymphoma / diagnosis,  pathology*
Skin Diseases / diagnosis,  pathology
Skin Neoplasms / diagnosis,  pathology*

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