| Acquisition of neural learning in cerebellum and cerebral cortex for smooth pursuit eye movements. | |
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MedLine Citation:
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PMID: 21900551 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We evaluated the emergence of neural learning in the frontal eye fields (FEF(SEM)) and the floccular complex of the cerebellum while monkeys learned a precisely timed change in the direction of pursuit eye movement. For each neuron, we measured the time course of changes in neural response across a learning session that comprised at least 100 repetitions of an instructive change in target direction. In both areas, the average population learning curves tracked the behavioral changes with high fidelity, consistent with possible roles in driving learning. However, the learning curves of individual neurons sometimes bore little relation to the smooth, monotonic progression of behavioral learning. In the FEF(SEM), neural learning was episodic. For individual neurons, learning appeared at different times during the learning session and sometimes disappeared by the end of the session. Different FEF(SEM) neurons expressed maximal learning at different times relative to the acquisition of behavioral learning. In the floccular complex, many Purkinje cells acquired learned simple-spike responses according to the same time course as behavioral learning and retained their learned responses throughout the learning session. A minority of Purkinje cells acquired learned responses late in the learning session, after behavioral learning had reached an asymptote. We conclude that learning in single neurons can follow a very different time course from behavioral learning. Both the FEF(SEM) and the floccular complex contain representations of multiple temporal components of learning, with different neurons contributing to learning at different times during the acquisition of a learned movement. |
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Authors:
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Jennifer X Li; Javier F Medina; Loren M Frank; Stephen G Lisberger |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: The Journal of neuroscience : the official journal of the Society for Neuroscience Volume: 31 ISSN: 1529-2401 ISO Abbreviation: J. Neurosci. Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-09-08 Completed Date: 2011-10-31 Revised Date: 2012-03-12 |
Medline Journal Info:
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Nlm Unique ID: 8102140 Medline TA: J Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 12716-26 Citation Subset: IM |
Affiliation:
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Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, California 94143-0444, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms Animals Behavior, Animal / physiology Cerebellum / cytology, physiology* Cerebral Cortex / cytology, physiology* Data Interpretation, Statistical Electrophysiological Phenomena Learning / physiology* Macaca mulatta Male Models, Statistical Neurons / physiology* Photic Stimulation Psychomotor Performance / physiology Purkinje Cells / physiology Pursuit, Smooth / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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MH077970/MH/NIMH NIH HHS; NS655982/NS/NINDS NIH HHS; P50 MH077970-05/MH/NIMH NIH HHS; //Howard Hughes Medical Institute; //Howard Hughes Medical Institute |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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