Document Detail


Acquisition of multidrug resistance transposon Tn6061 and IS6100-mediated large chromosomal inversions in Pseudomonas aeruginosa clinical isolates.
MedLine Citation:
PMID:  20110294     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pseudomonas aeruginosa is a major human opportunistic pathogen, especially for patients in intensive care units or with cystic fibrosis. Multidrug resistance is a common feature of this species. In a previous study we detected the ant(4')-IIb gene in six multiresistant clinical isolates of P. aeruginosa, and determination of the environment of the gene led to characterization of Tn6061. This 26 586 bp element, a member of the Tn3 family of transposons, carried 10 genes conferring resistance to six drug classes. The ant(4')-IIb sequence was flanked by directly repeated copies of ISCR6 in all but one of the strains studied, consistent with ISCR6-mediated gene acquisition. Tn6061 was chromosomally located in six strains and plasmid-borne in the remaining isolate, suggesting horizontal acquisition. Duplication-insertion of IS6100, that ended Tn6061, was responsible for large chromosomal inversions. Acquisition of Tn6061 and chromosomal inversions are further examples of intricate mechanisms that contribute to the genome plasticity of P. aeruginosa.
Authors:
Sébastien Coyne; Patrice Courvalin; Marc Galimand
Related Documents :
12830984 - Chromosomal polymorphism of mandarin vole, microtus mandarinus (rodentia).
18713754 - A position effect on trps1 is associated with ambras syndrome in humans and the koala p...
938974 - Geographic variation of the chromosomal polymorphism in drosophila flavopilosa.
20837604 - Chromosomal inversions, natural selection and adaptation in the malaria vector anophele...
19834534 - Limiting the persistence of a chromosome break diminishes its mutagenic potential.
6292464 - Simian virus 40 encapsidation: characterization of early intermediates.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-01-28
Journal Detail:
Title:  Microbiology (Reading, England)     Volume:  156     ISSN:  1465-2080     ISO Abbreviation:  Microbiology (Reading, Engl.)     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-03     Completed Date:  2010-08-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9430468     Medline TA:  Microbiology     Country:  England    
Other Details:
Languages:  eng     Pagination:  1448-58     Citation Subset:  IM    
Affiliation:
Institut Pasteur, Unité des Agents Antibactériens, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/GQ388247;  GU475048;  GU475049;  GU475050;  GU475051;  GU475052;  GU475053;  GU475054;  GU475055
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Base Sequence
Chromosome Inversion*
Chromosomes, Bacterial*
DNA Transposable Elements*
DNA, Bacterial
Drug Resistance, Multiple, Bacterial / genetics*
Humans
Molecular Sequence Data
Plasmids
Pseudomonas Infections / genetics,  microbiology
Pseudomonas aeruginosa / classification,  genetics*,  isolation & purification
Chemical
Reg. No./Substance:
0/DNA Transposable Elements; 0/DNA, Bacterial

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  A novel redox-sensing transcriptional regulator CyeR controls expression of an old yellow enzyme fam...
Next Document:  The 4.5S RNA component of the signal recognition particle is required for group A Streptococcus viru...