Document Detail


Acquisition of antibodies to variant antigens on the surface of Plasmodium falciparum-infected erythrocytes during pregnancy.
MedLine Citation:
PMID:  16621725     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pregnancy-associated malaria is characterized by Plasmodium falciparum adherence to chondroitin sulfate A (CSA) in placenta, through a particular variant surface antigen (VSA). VSA(CSA)-specific IgG are involved in protection against placental malaria. In order to assess the relationship between VSA(CSA)-specific antibody responses and parity as well as protection against placental malaria, the occurrence of P. falciparum infection was assessed in 306 pregnant women from a low malaria transmission area of Senegal. Anti-VSA(CSA) antibodies against three placental parasite isolates were measured by flow cytometry, at enrollment and delivery. Placental infection prevalence rates were highest in primigravidae, but no clear decreasing trend was observed from the second pregnancy onwards. Anti-VSA(CSA) antibody prevalence rates increased with parity. Both anti-VSA(CSA) antibody prevalence rates and levels increased during pregnancy only in women infected with P. falciparum. Although a single or a very limited number of P. falciparum infections were able to induce an anti-VSA(CSA) antibody response, the level or the quality of this response did not appear to confer protection against placental malaria infection.
Authors:
Nadine Fievet; Jean Yves Le Hesran; Gilles Cottrell; Souleymane Doucoure; Ibrahima Diouf; Jean Louis Ndiaye; Gwladys Bertin; Oumar Gaye; Sokhna Sow; Philippe Deloron
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-04-18
Journal Detail:
Title:  Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases     Volume:  6     ISSN:  1567-1348     ISO Abbreviation:  Infect. Genet. Evol.     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-10-18     Completed Date:  2007-02-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101084138     Medline TA:  Infect Genet Evol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  459-63     Citation Subset:  IM    
Affiliation:
Institut de Recherche pour le Développement, UR 010, Mother and Child Health in the Tropics, BP1386 CP 18524 Dakar, Senegal.
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MeSH Terms
Descriptor/Qualifier:
Adult
Animals
Antibodies, Protozoan / blood,  immunology*
Antigens, Protozoan / blood,  immunology*
Erythrocytes / immunology*,  parasitology*
Female
Humans
Malaria, Falciparum / immunology*,  parasitology
Plasmodium falciparum / immunology*
Pregnancy
Pregnancy Complications, Parasitic / blood,  immunology*,  parasitology
Chemical
Reg. No./Substance:
0/Antibodies, Protozoan; 0/Antigens, Protozoan

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