| Acquired von Willebrand syndrome as side effect of valproic acid therapy in children is rare. | |
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MedLine Citation:
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PMID: 19404518 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To determine the frequency and clinical relevance of acquired von Willebrand syndrome (aVWS) due to antiepileptic therapy by valproic acid, we investigated 50 consecutive children in three neuropediatric institutions. Coagulation factors were determined in local laboratories before and three times after starting therapy with valproic acid. Parameters of von Willebrand factor (VWF) were additionally investigated in a reference laboratory including multimeric analysis. Significant changes in the coagulation system were found concerning fibrinogen (decreased from 287 +/- 70 mg/dl to 222 +/- 67 mg/dl; p < 0.001) and platelet count. Changes of VWF parameters were also found but no patient developed laboratory defined aVWS. We conclude that the bleeding tendency observed in some children undergoing antiepileptic therapy with valproic acid is not due to aVWS. |
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Authors:
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Wolfgang Eberl; U Budde; K Bentele; H-J Christen; R Knapp; A Mey; Reinhard Schneppenheim |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Hämostaseologie Volume: 29 ISSN: 0720-9355 ISO Abbreviation: Hamostaseologie Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-04-30 Completed Date: 2009-07-07 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 8204531 Medline TA: Hamostaseologie Country: Germany |
Other Details:
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Languages: eng Pagination: 137-42 Citation Subset: IM |
Affiliation:
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Department of Paediatrics and Coagulation Laboratory, Klinikum Braunschweig gGmbH, 38118 Braunschweig, Germany. w.eberl@klinikum-braunschweig.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anticonvulsants
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adverse effects* Child Factor VIII / metabolism Humans Seizures / drug therapy Valproic Acid / adverse effects*, therapeutic use von Willebrand Diseases / chemically induced*, epidemiology von Willebrand Factor / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants; 0/von Willebrand Factor; 9001-27-8/Factor VIII; 99-66-1/Valproic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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