| Acquired vitamin K-dependent carboxylation deficiency in liver disease. | |
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MedLine Citation:
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PMID: 6165889 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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gamma-Carboxyglutamic acid residues on prothrombin are synthesized from glutamic acid on a prothrombin precursor in the liver through a vitamin K-dependent carboxylase. In the absence of vitamin K or in the presence of vitamin K antagonists, an inert form of prothrombin - abnormal prothrombin - circulates in the blood. We have developed specific immunoassays for native and abnormal human prothrombin. The prothrombin concentration in our normal subjects was 108 +/- 19 microgram per milliliter. The abnormal-prothrombin concentration varied over four orders of magnitude between the limits of detection in normal plasma and the level in patients with cirrhosis (0 to 5 microgram per milliliter), acute hepatitis (0 to 33 microgram per milliliter), or vitamin K deficiency (32 to 100 microgram per milliliter) and in those treated with sodium warfarin (12 to 65 microgram per milliliter). These studies indicate that abnormal prothrombin is not a component of normal plasma but appears in a variety of hepatic and nutritional disorders characterized by impaired hepatic vitamin-K-dependent carboxylation. |
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Authors:
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R A Blanchard; B C Furie; M Jorgensen; S F Kruger; B Furie |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The New England journal of medicine Volume: 305 ISSN: 0028-4793 ISO Abbreviation: N. Engl. J. Med. Publication Date: 1981 Jul |
Date Detail:
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Created Date: 1981-08-27 Completed Date: 1981-08-27 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0255562 Medline TA: N Engl J Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 242-8 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Carbon-Carbon Ligases* Epitopes Female Hepatitis / enzymology Humans Ligases / deficiency* Liver / enzymology Liver Cirrhosis / enzymology Liver Diseases / blood, enzymology* Male Middle Aged Prothrombin / biosynthesis*, immunology, isolation & purification Prothrombin Time Vitamin K Deficiency / enzymology Warfarin / adverse effects |
| Grant Support | |
ID/Acronym/Agency:
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1 F32 HL 05630/HL/NHLBI NIH HHS; HL 18834/HL/NHLBI NIH HHS; HL 21543/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Epitopes; 81-81-2/Warfarin; 9001-26-7/Prothrombin; EC 6.-/Ligases; EC 6.4.-/Carbon-Carbon Ligases; EC 6.4.-/glutamyl carboxylase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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