Document Detail


Acquired vitamin K-dependent carboxylation deficiency in liver disease.
MedLine Citation:
PMID:  6165889     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
gamma-Carboxyglutamic acid residues on prothrombin are synthesized from glutamic acid on a prothrombin precursor in the liver through a vitamin K-dependent carboxylase. In the absence of vitamin K or in the presence of vitamin K antagonists, an inert form of prothrombin - abnormal prothrombin - circulates in the blood. We have developed specific immunoassays for native and abnormal human prothrombin. The prothrombin concentration in our normal subjects was 108 +/- 19 microgram per milliliter. The abnormal-prothrombin concentration varied over four orders of magnitude between the limits of detection in normal plasma and the level in patients with cirrhosis (0 to 5 microgram per milliliter), acute hepatitis (0 to 33 microgram per milliliter), or vitamin K deficiency (32 to 100 microgram per milliliter) and in those treated with sodium warfarin (12 to 65 microgram per milliliter). These studies indicate that abnormal prothrombin is not a component of normal plasma but appears in a variety of hepatic and nutritional disorders characterized by impaired hepatic vitamin-K-dependent carboxylation.
Authors:
R A Blanchard; B C Furie; M Jorgensen; S F Kruger; B Furie
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The New England journal of medicine     Volume:  305     ISSN:  0028-4793     ISO Abbreviation:  N. Engl. J. Med.     Publication Date:  1981 Jul 
Date Detail:
Created Date:  1981-08-27     Completed Date:  1981-08-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0255562     Medline TA:  N Engl J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  242-8     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Carbon-Carbon Ligases*
Epitopes
Female
Hepatitis / enzymology
Humans
Ligases / deficiency*
Liver / enzymology
Liver Cirrhosis / enzymology
Liver Diseases / blood,  enzymology*
Male
Middle Aged
Prothrombin / biosynthesis*,  immunology,  isolation & purification
Prothrombin Time
Vitamin K Deficiency / enzymology
Warfarin / adverse effects
Grant Support
ID/Acronym/Agency:
1 F32 HL 05630/HL/NHLBI NIH HHS; HL 18834/HL/NHLBI NIH HHS; HL 21543/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Epitopes; 81-81-2/Warfarin; 9001-26-7/Prothrombin; EC 6.-/Ligases; EC 6.4.-/Carbon-Carbon Ligases; EC 6.4.-/glutamyl carboxylase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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