Document Detail

Acquired reactive perforating collagenosis: a clinicopathologic study of 15 cases from Saudi Arabia.
MedLine Citation:
PMID:  20205317     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Perforating dermatoses include a family of disease characterized by transepidermal elimination of collagen. Despite being described many years ago in association with systemic disease, it is still clinically misdiagnosed. OBJECTIVE: A retrospective clinical and pathologic review that will increase clinical and pathologic diagnostic awareness of this entity and explore associated systemic disease. PATIENTS AND METHODS: In this report, we present from Saudi Arabia for the first time details of a series of patients seen at the King Abdulaziz Medical City, WR, Jeddah, Saudi Arabia, during the period 2002-2009. RESULTS: The study revealed 15 histologically confirmed cases of acquired reactive perforating collagenosis (ARPC). Patients were predominantly adult females with a mean age of 54 years. The lesions were pruritic, predominantly multiple, erythematous excoriated papules and umblicated nodules centrally crusted with an average duration of 6 months, involving the extremities with or without the trunk in 12 patients. Associated systemic disease included diabetes mellitus in 12 patients and chronic renal failure on dialysis in 8 patients. The provisional clinical differential diagnosis included perforating collagenosis in only eight patients.CONCLUSION: ARPC is not uncommon in Saudi Arabia. The noduloulcerative lesions involve predominantly the extremities, and diabetes mellitus is the most common associate. It is hoped that this article will increase awareness for recognition of this entity to start appropriate therapy.
M B Satti; A H Aref; A A Raddadi; F A Al-Ghamdi
Related Documents :
3950037 - Membranous glomerulonephritis.
17229877 - Renal involvement in patients with autoimmune pancreatitis: ct and mr imaging findings.
365407 - The long-term prognosis of patients with focal segmental glomerulosclerosis.
22672827 - Quantitative analysis of intestinal gas in patients with acute pancreatitis.
1172207 - Nationwide survey of multiple sclerosis in japan. clinical analysis of 1,084 cases.
6611387 - The inability of oral leucovorin to elevate csf 5-methyl-tetrahydrofolate following hig...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the European Academy of Dermatology and Venereology : JEADV     Volume:  24     ISSN:  1468-3083     ISO Abbreviation:  J Eur Acad Dermatol Venereol     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-03-04     Completed Date:  2010-06-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9216037     Medline TA:  J Eur Acad Dermatol Venereol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  223-7     Citation Subset:  IM    
Departments of Pathology, King Abdulaziz Medical City, Jeddah, Saudi Arabia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Collagen / metabolism*
Middle Aged
Saudi Arabia
Skin Ulcer / metabolism,  pathology*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Science letters: Proteomic analysis of differentially expressed proteins in mice with concanavalin A...
Next Document:  Study on association between polymorphism of HLA-DRB1 alleles and Beh?et's disease.