Document Detail

Acquired pericentric inversion of chromosome 9 in acute myeloid leukemia.
MedLine Citation:
PMID:  19193987     Owner:  NLM     Status:  MEDLINE    
Pericentric inversion of chromosome 9 involving the qh region is relatively common as a constitutional genetic aberration without any apparent phenotypic consequences. However, it has not been established as an acquired abnormality in cancer. Among the three patients reported so far in the literature with acquired inv(9), only one had acute myeloid leukemia (AML). Here we describe an unique case where both chromosomes 9 presented with an acquired pericentric inversion with breakpoints at 9p13 and 9q12 respectively, in a AML patient with aberrant CD7 and CD9 positivity. Additionally, one der(9) also showed short arm deletion at 9p21 to the centromeric region and including the p16 gene. The constitutional karyotype was normal. This is probably the first report describing an acquired inv(9) involving both chromosomes 9 in AML. The possible significance of this inversion is discussed.
A M Udayakumar; A V Pathare; D Dennison; J A Raeburn
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of applied genetics     Volume:  50     ISSN:  1234-1983     ISO Abbreviation:  J. Appl. Genet.     Publication Date:  2009  
Date Detail:
Created Date:  2009-02-05     Completed Date:  2009-07-01     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9514582     Medline TA:  J Appl Genet     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  73-6     Citation Subset:  IM    
Cytogenetics Laboratory, Department of Genetics, College of Medicine and Health Sciences, Sultan Qaboos University, P.O.Box 35, P.C.123, Muscat, Sultanate of Oman.
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MeSH Terms
Antigens, CD / biosynthesis
Antigens, CD7 / biosynthesis
Chromosome Banding
Chromosome Deletion
Chromosome Inversion*
Chromosome Mapping
Chromosomes, Human, Pair 9*
In Situ Hybridization, Fluorescence
Leukemia, Myeloid, Acute / genetics*
Membrane Glycoproteins / biosynthesis
Reg. No./Substance:
0/Antigens, CD; 0/Antigens, CD7; 0/CD9 antigen; 0/Membrane Glycoproteins

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