| Acquired local resistance to burns: prevention of its acquisition by chlorpromazine. | |
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MedLine Citation:
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PMID: 6616306 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chlorpromazine administered to Sprague-Dawley rats 30 minutes prior to burning dramatically minimized burn oedema by a factor of 7 compared with controls. Reburning of the rats 72 hours later demonstrated acquisition of local (but not systemic) resistance to subsequent burning among the control animals, and prevention of the acquisition of local resistance by the previously treated chlorpromazine group. The pharmacological actions of chlorpromazine are discussed in relation to the above phenomena, and mechanisms for the results obtained are described. |
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Authors:
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R R Bibi; M Babyatsky; S M Levenson |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Burns, including thermal injury Volume: 9 ISSN: 0305-4179 ISO Abbreviation: Burns Incl Therm Inj Publication Date: 1983 Jul |
Date Detail:
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Created Date: 1983-11-23 Completed Date: 1983-11-23 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7512054 Medline TA: Burns Incl Therm Inj Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 387-93 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Burns / complications*, diagnosis Chlorpromazine / therapeutic use* Edema / diagnosis, etiology, prevention & control* Hindlimb / injuries Male Rats Rats, Inbred Strains |
| Grant Support | |
ID/Acronym/Agency:
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5 K06 GM14208/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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50-53-3/Chlorpromazine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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