Document Detail

Acquired hemophilia in a patient with systemic lupus erythematosus: a case report and literature review.
MedLine Citation:
PMID:  18551353     Owner:  NLM     Status:  MEDLINE    
We report the case of a 38-year-old female patient with systemic lupus erythematosus (SLE) who developed acquired hemophilia caused by factor VIII (FVIII) inhibitors. She manifested spontaneous bleeding symptoms such as ecchymoses and hematuria. Laboratory findings showed an isolated prolongation of the activated partial thromboplastin time, reduced FVIII activity, and a high titer of FVIII inhibitors. She was successfully treated with oral predonisolone and cyclosporine in combination with steroid and cyclophosphamide pulse therapy.
Mitsuteru Akahoshi; Kumiko Aizawa; Shuji Nagano; Hisako Inoue; Atsushi Sadanaga; Yojiro Arinobu; Hiroaki Niiro; Hitoshi Nakashima
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Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2008-06-13
Journal Detail:
Title:  Modern rheumatology / the Japan Rheumatism Association     Volume:  18     ISSN:  1439-7595     ISO Abbreviation:  Mod Rheumatol     Publication Date:  2008  
Date Detail:
Created Date:  2008-10-06     Completed Date:  2009-04-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100959226     Medline TA:  Mod Rheumatol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  511-5     Citation Subset:  IM    
Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, and Department of Internal Medicine, Chihaya Hospital, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
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MeSH Terms
Autoantibodies / immunology*
Ecchymosis / etiology
Factor VIII / immunology*
Hemophilia A / complications,  immunology*
Lupus Erythematosus, Systemic / complications,  immunology*
Reg. No./Substance:
0/Autoantibodies; 9001-27-8/Factor VIII

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