Document Detail

Acquired hemophagocytic lymphohistiocytosis associated with multiple myeloma.
MedLine Citation:
PMID:  20358309     Owner:  NLM     Status:  In-Data-Review    
Acquired or secondary hemophagocytic lymphohistiocytosis (sHLH) is a life-threatening hyperinflammation syndrome caused mostly by various infectious agents, autoimmune disorders or malignancy. So far, only anecdotal cases of sHLH associated with multiple myeloma have been published. We provide a review of all these reports and include a previously not published case of myeloma-associated sHLH in a 59-year-old male with complex partial epilepsy. Due to aggressive course of sHLH, increased awareness is indicated in all patients with malignancies which develop unremitting fever, cytopenia and splenomegaly. Early diagnosis and immediate introduction of adequate therapy is crucial for the outcome of HLH.
Maciej Machaczka; Johan Vaktnäs; Monika Klimkowska; Hareth Nahi; Hans Hägglund
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Publication Detail:
Type:  Journal Article     Date:  2010-04-01
Journal Detail:
Title:  Medical oncology (Northwood, London, England)     Volume:  28     ISSN:  1559-131X     ISO Abbreviation:  Med. Oncol.     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-05-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9435512     Medline TA:  Med Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  539-43     Citation Subset:  IM    
Hematology Center Karolinska, M54, Karolinska University Hospital Huddinge, 141 86, Stockholm, Sweden,
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