Document Detail

Acquired haemophilia A in women postpartum: management of bleeding episodes and natural history of the factor VIII inhibitor.
MedLine Citation:
PMID:  9293858     Owner:  NLM     Status:  MEDLINE    
The present study reports on the treatment of bleeding episodes and the natural history of factor VIII inhibitors in 4 patients with acquired haemophilia A postpartum. Low titre type II factor VIII inhibitors in 3 patients and high titre type I inhibitor in 1 patient became apparent immediately to 7 months after delivery. High dose human factor VIII concentrate substitution was effective in controlling bleeding episodes in two cases of factor VIII inhibitor type II, but ineffective in 1 patient with high titre type I factor VIII inhibitor. High dose gammaglobulin intravenously in 1 patient with type II factor VIII inhibitor induced a partial correction of factor VIIIc levels for 2 wk. Immunosuppressive treatment in all 4 patients with acquired haemophilia A postpartum did not reduce the potency of the factor VIII inhibitors. The low titre type II inhibitors spontaneously disappeared in all 3 patients within a few months to 1 yr after discontinuation of the immunosuppressive treatment. The high titre type I factor VIII inhibitor persisted for more than 24 yr. We conclude that immunosuppression in 4 women with acquired haemophilia A postpartum did not significantly affect the factor VIII inhibitor titre.
J J Michiels; K Hamulyak; H K Nieuwenhuis; I Novakova; H H van Vliet
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of haematology     Volume:  59     ISSN:  0902-4441     ISO Abbreviation:  Eur. J. Haematol.     Publication Date:  1997 Aug 
Date Detail:
Created Date:  1997-10-01     Completed Date:  1997-10-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8703985     Medline TA:  Eur J Haematol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  105-9     Citation Subset:  IM    
Haematology, Haemostasis and Thrombosis Scientific Center, Goodheart Institute Rotterdam, The Netherlands.
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MeSH Terms
Cyclophosphamide / therapeutic use
Factor VIII / antagonists & inhibitors*,  immunology*,  therapeutic use
Hemophilia A / etiology*,  therapy
Immunosuppressive Agents / therapeutic use
Postpartum Period
Prednisone / therapeutic use
Pregnancy Complications, Hematologic*
Time Factors
Reg. No./Substance:
0/Immunosuppressive Agents; 50-18-0/Cyclophosphamide; 53-03-2/Prednisone; 9001-27-8/Factor VIII

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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