Document Detail

Acquired haemophilia due to factor VIII inhibitors in ovarian hyperstimulation syndrome: case report.
MedLine Citation:
PMID:  12615815     Owner:  NLM     Status:  MEDLINE    
A 31-year-old nulligravida woman developed an acquired factor VIII inhibitor associated with severe ovarian hyperstimulation syndrome (OHSS). She developed haematouria, ecchymosis, and intramuscular bleeding following the severe OHSS. Laboratory examinations showed a markedly prolonged activated partial thromboplastin time and a low level of factor VIII activity. Treatment with prothrombin complex concentrate and factor VIII inhibitor bypassing agent was successful in reducing the inhibitor so that she delivered a healthy baby via spontaneous vaginal delivery. Acquired haemophilia is a life-threatening disorder. This is the first case report of acquired haemophilia in OHSS.
Tomoko Nakauchi-Tanaka; Satoshi Sohda; Katsumi Someya; Keiko Kono; Hiromi Hamada; Hiroyuki Yoshikawa
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  18     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-03-04     Completed Date:  2003-10-30     Revised Date:  2007-10-12    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  England    
Other Details:
Languages:  eng     Pagination:  506-8     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Institute of Clinical Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305, Japan.
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MeSH Terms
Blood Coagulation Factors / therapeutic use
Delivery, Obstetric
Factor VIII / antagonists & inhibitors*
Hemophilia A / drug therapy,  etiology*
Infant, Newborn
Ovarian Hyperstimulation Syndrome / complications*,  metabolism*
Reg. No./Substance:
0/Blood Coagulation Factors; 37224-63-8/prothrombin complex concentrates; 78690-39-8/Feiba; 9001-27-8/Factor VIII
Comment In:
Hum Reprod. 2007 Aug;22(8):2348-9   [PMID:  17513318 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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