| Acquired haemophilia due to factor VIII inhibitors in ovarian hyperstimulation syndrome: case report. | |
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MedLine Citation:
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PMID: 12615815 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 31-year-old nulligravida woman developed an acquired factor VIII inhibitor associated with severe ovarian hyperstimulation syndrome (OHSS). She developed haematouria, ecchymosis, and intramuscular bleeding following the severe OHSS. Laboratory examinations showed a markedly prolonged activated partial thromboplastin time and a low level of factor VIII activity. Treatment with prothrombin complex concentrate and factor VIII inhibitor bypassing agent was successful in reducing the inhibitor so that she delivered a healthy baby via spontaneous vaginal delivery. Acquired haemophilia is a life-threatening disorder. This is the first case report of acquired haemophilia in OHSS. |
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Authors:
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Tomoko Nakauchi-Tanaka; Satoshi Sohda; Katsumi Someya; Keiko Kono; Hiromi Hamada; Hiroyuki Yoshikawa |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Human reproduction (Oxford, England) Volume: 18 ISSN: 0268-1161 ISO Abbreviation: Hum. Reprod. Publication Date: 2003 Mar |
Date Detail:
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Created Date: 2003-03-04 Completed Date: 2003-10-30 Revised Date: 2007-10-12 |
Medline Journal Info:
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Nlm Unique ID: 8701199 Medline TA: Hum Reprod Country: England |
Other Details:
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Languages: eng Pagination: 506-8 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Institute of Clinical Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Coagulation Factors / therapeutic use Delivery, Obstetric Factor VIII / antagonists & inhibitors* Female Hemophilia A / drug therapy, etiology* Humans Infant, Newborn Male Ovarian Hyperstimulation Syndrome / complications*, metabolism* Pregnancy |
| Chemical | |
Reg. No./Substance:
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0/Blood Coagulation Factors; 37224-63-8/prothrombin complex concentrates; 78690-39-8/Feiba; 9001-27-8/Factor VIII |
| Comments/Corrections | |
Comment In:
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Hum Reprod. 2007 Aug;22(8):2348-9
[PMID:
17513318
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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