Document Detail


Acquired factor v inhibitor developing after treatment with dabigatran etexilate methanesulfonate: a case report and review of the literature.
MedLine Citation:
PMID:  25332596     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
A 90-year-old man presented with subcutaneous ecchymoses. He had been under treatment with dabigatran etexilate methanesulfonate (DEM). Prolonged APTT and decreased PT was developed 2 months after the start of DEM, more prolonged 6 months later. DEM was discontinued, the coagulopathy did not improve. Factor V activity was decreased, along with appearance of coagulation factor V inhibitor (FVI). He did not have antiphospholipid syndrome or malignancy. He was diagnosed as having acquired FVI caused by DEM. Steroid pulse therapy was effective. There have been 74 reported cases of AFVI induced by drug treatment, but none after treatment with DEM.
Authors:
Yasunobu Sekiguchi; Hitomi Yoshikawa; Asami Shimada; Hidenori Imai; Mutsumi Wakabayashi; Keiji Sugimoto; Noriko Nakamura; Tomohiro Sawada; Tetsuo Ichinose; Dai Ozaki; Norio Komatsu; Masaaki Noguchi
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Publication Detail:
Type:  Journal Article     Date:  2014-03-06
Journal Detail:
Title:  Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion     Volume:  30     ISSN:  0971-4502     ISO Abbreviation:  Indian J Hematol Blood Transfus     Publication Date:  2014 Sep 
Date Detail:
Created Date:  2014-10-21     Completed Date:  2014-10-21     Revised Date:  2014-10-23    
Medline Journal Info:
Nlm Unique ID:  9425818     Medline TA:  Indian J Hematol Blood Transfus     Country:  India    
Other Details:
Languages:  eng     Pagination:  275-9     Citation Subset:  -    
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