Document Detail

Acquired factor X and antithrombin III deficiency in a patient with primary amyloidosis and nephrotic syndrome.
MedLine Citation:
PMID:  3876596     Owner:  NLM     Status:  MEDLINE    
A 45-year-old man with primary amyloidosis was initially seen with nephrotic syndrome. Factor X was found to be 5% and antithrombin III (AT III) 45% of normal plasma values. During an 11-month period, despite severe factor X deficiency, the patient did not have any bleeding complications. He developed progressive renal failure and AT III levels increased to normal, at which time he developed severe bleeding complications. These findings suggest a protective role of AT III deficiency against bleeding in a patient with severe factor X deficiency.
M Quitt; E Aghai; M David; R Kohan; Y Ben Ari; P Froom
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Scandinavian journal of haematology     Volume:  35     ISSN:  0036-553X     ISO Abbreviation:  Scand J Haematol     Publication Date:  1985 Aug 
Date Detail:
Created Date:  1985-11-20     Completed Date:  1985-11-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0404507     Medline TA:  Scand J Haematol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  155-7     Citation Subset:  IM    
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MeSH Terms
Amyloidosis / complications*,  drug therapy
Antithrombin III Deficiency*
Blood Coagulation Tests
Colchicine / therapeutic use
Factor X Deficiency / complications*
Gastrointestinal Hemorrhage / etiology
Hypoprothrombinemias / complications*
Kidney / pathology
Melphalan / therapeutic use
Middle Aged
Nephrotic Syndrome / complications*
Prednisone / therapeutic use
Splenectomy / adverse effects
Reg. No./Substance:
148-82-3/Melphalan; 53-03-2/Prednisone; 64-86-8/Colchicine

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