Document Detail

Acquired factor VIII deficiency after consuming the dried gallbladder of a cobra, Naja naja.
MedLine Citation:
PMID:  21120211     Owner:  NLM     Status:  In-Data-Review    
Acquired factor VIII deficiency is very rare, often fatal. It is associated with pregnancy, autoimmune diseases, malignancy, and drugs, although no underlying cause is found in 50%. A 49-year-old male was referred with right shoulder bruising. The coagulation test showed a prolonged activated partial thromboplastin time. The factor VIII level was less than 1%, and the factor VIII inhibitor antibody titer was 246 Bethesda units/mL. The findings were compatible with acquired factor VIII deficiency. He had consumed the dried gallbladder of a cobra, Naja naja, for two weeks, it contained venom. After the initial treatment with factor VIII, he did not take supplemental coagulation factor VIII. The patient was readmitted with left forearm swelling. He lost consciousness suddenly and brain computed tomography (CT) revealed a subdural hematoma. Despite administering recombinant factor VII, his bleeding was not controlled and he died.
Hyun Ju Kim; Won Sik Lee; Young Jin Lee; Hyun Soo Jun; Su-Kil Seo; Young-Don Joo
Publication Detail:
Type:  Journal Article     Date:  2010-09-30
Journal Detail:
Title:  The Korean journal of hematology     Volume:  45     ISSN:  2092-9129     ISO Abbreviation:  Korean J Hematol     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-12-01     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101486388     Medline TA:  Korean J Hematol     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  205-7     Citation Subset:  -    
Department of Hemato-Oncology, Busan Paik Hospital Inje University, Busan, Korea.
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