Document Detail

Acquired epidermolysis bullosa with the clinical feature of Brunsting-Perry cicatricial bullous pemphigoid.
MedLine Citation:
PMID:  1998371     Owner:  NLM     Status:  MEDLINE    
A 56-year-old woman with the typical clinical feature of cicatricial bullous pemphigoid of the Brunsting-Perry type was studied. Histologic examination of a lesion skin biopsy specimen demonstrated a subepidermal blister. Direct immunofluorescence microscopy revealed linear deposits of IgG, IgM, and C3 located on both the roof and the floor of the blister. Immunofluorescence antigen mapping using cryostat sections of a spontaneous blister and antisera against defined basement membrane components localized the bullous pemphigoid antigen and type IV collagen in the roof of the blister. This dermal type of blister formation was confirmed by electron microscopy, which showed the cleavage level below the lamina densa. In direct immunoelectron microscopy, granular deposits of C3 and IgG were found attached to and just beneath the lamina densa in a pattern identical to the distribution of anchoring fibrils. These findings are diagnostic of acquired epidermolysis bullosa, a blistering disease that has much more clinical heterogeneity than previously suggested.
G Kurzhals; W Stolz; M Meurer; J Kunze; O Braun-Falco; T Krieg
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Archives of dermatology     Volume:  127     ISSN:  0003-987X     ISO Abbreviation:  Arch Dermatol     Publication Date:  1991 Mar 
Date Detail:
Created Date:  1991-04-01     Completed Date:  1991-04-01     Revised Date:  2008-03-17    
Medline Journal Info:
Nlm Unique ID:  0372433     Medline TA:  Arch Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  391-5     Citation Subset:  AIM; IM    
Department of Dermatology, Ludwig-Maximilians, University of Munich, Federal Republic of Germany.
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MeSH Terms
Complement C3 / analysis
Diagnosis, Differential
Epidermolysis Bullosa Acquisita / diagnosis*,  immunology
Fluorescent Antibody Technique
Immunoglobulin G / analysis
Immunoglobulin M / analysis
Microscopy, Immunoelectron
Middle Aged
Pemphigoid, Benign Mucous Membrane / diagnosis,  immunology
Pemphigoid, Bullous / diagnosis*,  immunology
Reg. No./Substance:
0/Complement C3; 0/Immunoglobulin G; 0/Immunoglobulin M

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