Document Detail

Acquired cystic disease in chronically rejected renal transplants.
MedLine Citation:
PMID:  1627755     Owner:  NLM     Status:  MEDLINE    
Acquired cystic disease has been documented to complicate most forms of chronic renal damage; it has only infrequently been described in transplanted kidneys. Five patients with noncystic ESRD and chronically rejected transplants in which acquired cystic disease arose are reported. The diagnosis of acquired cystic disease was established in examination of transplant nephrectomies from four patients and a core biopsy from the fifth. The allografts were in place from 44 to 80 months; three patients were treated with hemodialysis before the diagnosis of acquired cystic disease, whereas two received peritoneal dialysis. Three of the four patients evaluated had cysts in the native kidneys. Although papillary hyperplasia of lining epithelium was evident in four specimens, only one kidney was the site of neoplasms in the form of multiple small tubular adenomas. No malignant neoplasms were noted in this study or in the few similar previous ones; however, it is possible that chronically rejected transplanted kidneys may harbor neoplasms with the same malignant potential as those in acquired cystic disease in native kidneys.
W Y Chung; C C Nast; R B Ettenger; G M Danoviton; H J Ward; A H Cohen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the American Society of Nephrology : JASN     Volume:  2     ISSN:  1046-6673     ISO Abbreviation:  J. Am. Soc. Nephrol.     Publication Date:  1992 Feb 
Date Detail:
Created Date:  1992-08-20     Completed Date:  1992-08-20     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  9013836     Medline TA:  J Am Soc Nephrol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1298-301     Citation Subset:  IM    
Department of Pathology, Harbor-UCLA Medical Center, Torrance.
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MeSH Terms
Graft Rejection*
Kidney Diseases, Cystic / etiology*,  pathology
Kidney Transplantation / immunology*
Middle Aged
Retrospective Studies

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