Document Detail

Acquired coenzyme Q10 deficiency in children with recurrent food intolerance and allergies.
MedLine Citation:
PMID:  20817046     Owner:  NLM     Status:  In-Process    
The current study evaluated 23 children (ages 2-16 years) with recurrent food intolerance and allergies for CoQ10 deficiency and mitochondrial abnormalities. Muscle biopsies were tested for CoQ10 levels, pathology, and mitochondrial respiratory chain (MRC) activities. Group 2 (age >10 years; n = 9) subjects had significantly decreased muscle CoQ10 than Group 1 (age <10 y; n = 14) subjects (p = 0.001) and 16 controls (p<0.05). MRC activities were significantly lower in Group 2 than in Group 1 (p<0.05). Muscle CoQ10 levels in study subjects were significantly correlated with duration of illness (adjusted r(2) = 0.69; p = 0.012; n = 23). Children with recurrent food intolerance and allergies may acquire CoQ10 deficiency with disease progression.
Michael V Miles; Philip E Putnam; Lili Miles; Peter H Tang; Antonius J DeGrauw; Brenda L Wong; Paul S Horn; Heather L Foote; Marc E Rothenberg
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Publication Detail:
Type:  Journal Article     Date:  2010-09-15
Journal Detail:
Title:  Mitochondrion     Volume:  11     ISSN:  1872-8278     ISO Abbreviation:  Mitochondrion     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100968751     Medline TA:  Mitochondrion     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  127-35     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
Division of Pathology and Laboratory Medicine, Department of Pediatrics, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, ML 2015, 3333 Burnet Ave, Cincinnati, OH 45229-3039, USA.
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