| Acquired coenzyme Q10 deficiency in children with recurrent food intolerance and allergies. | |
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MedLine Citation:
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PMID: 20817046 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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The current study evaluated 23 children (ages 2-16 years) with recurrent food intolerance and allergies for CoQ10 deficiency and mitochondrial abnormalities. Muscle biopsies were tested for CoQ10 levels, pathology, and mitochondrial respiratory chain (MRC) activities. Group 2 (age >10 years; n = 9) subjects had significantly decreased muscle CoQ10 than Group 1 (age <10 y; n = 14) subjects (p = 0.001) and 16 controls (p<0.05). MRC activities were significantly lower in Group 2 than in Group 1 (p<0.05). Muscle CoQ10 levels in study subjects were significantly correlated with duration of illness (adjusted r(2) = 0.69; p = 0.012; n = 23). Children with recurrent food intolerance and allergies may acquire CoQ10 deficiency with disease progression. |
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Authors:
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Michael V Miles; Philip E Putnam; Lili Miles; Peter H Tang; Antonius J DeGrauw; Brenda L Wong; Paul S Horn; Heather L Foote; Marc E Rothenberg |
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Publication Detail:
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Type: Journal Article Date: 2010-09-15 |
Journal Detail:
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Title: Mitochondrion Volume: 11 ISSN: 1872-8278 ISO Abbreviation: Mitochondrion Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100968751 Medline TA: Mitochondrion Country: Netherlands |
Other Details:
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Languages: eng Pagination: 127-35 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier B.V. and Mitochondria Research Society. All rights reserved. |
Affiliation:
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Division of Pathology and Laboratory Medicine, Department of Pediatrics, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, ML 2015, 3333 Burnet Ave, Cincinnati, OH 45229-3039, USA. michael.miles@cchmc.org |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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