Document Detail


Acquired coenzyme Q10 deficiency in children with recurrent food intolerance and allergies.
MedLine Citation:
PMID:  20817046     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
The current study evaluated 23 children (ages 2-16 years) with recurrent food intolerance and allergies for CoQ10 deficiency and mitochondrial abnormalities. Muscle biopsies were tested for CoQ10 levels, pathology, and mitochondrial respiratory chain (MRC) activities. Group 2 (age >10 years; n = 9) subjects had significantly decreased muscle CoQ10 than Group 1 (age <10 y; n = 14) subjects (p = 0.001) and 16 controls (p<0.05). MRC activities were significantly lower in Group 2 than in Group 1 (p<0.05). Muscle CoQ10 levels in study subjects were significantly correlated with duration of illness (adjusted r(2) = 0.69; p = 0.012; n = 23). Children with recurrent food intolerance and allergies may acquire CoQ10 deficiency with disease progression.
Authors:
Michael V Miles; Philip E Putnam; Lili Miles; Peter H Tang; Antonius J DeGrauw; Brenda L Wong; Paul S Horn; Heather L Foote; Marc E Rothenberg
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Publication Detail:
Type:  Journal Article     Date:  2010-09-15
Journal Detail:
Title:  Mitochondrion     Volume:  11     ISSN:  1872-8278     ISO Abbreviation:  Mitochondrion     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100968751     Medline TA:  Mitochondrion     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  127-35     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
Affiliation:
Division of Pathology and Laboratory Medicine, Department of Pediatrics, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, ML 2015, 3333 Burnet Ave, Cincinnati, OH 45229-3039, USA. michael.miles@cchmc.org
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