Document Detail

Acquired autoimmunity after viral vaccination is caused by molecular mimicry and antigen complimentarity in the presence of an immunologic adjuvant and specific HLA patterns.
MedLine Citation:
PMID:  17630224     Owner:  NLM     Status:  MEDLINE    
Acquired autoimmunity syndromes occur after viral vaccinations. Molecular mimicry is involved in these phenomena as is the necessity for the presence of two chemically complimentary antigens and an immunologic adjuvant. The HLA pattern of the host is also an important factor. The example used to explain these phenomena is demyelinating disease that follows hepatitis B vaccination. The somatic antigen of the hepatitis B virus in the vaccine has chemical complimentarity with the Epstein-Barr virus antigen in the vaccine recipient. The Epstein-Barr virus shows molecular mimicry with human myelin. The immunologic adjuvant is either present in the vaccine or muramyl peptides in the individual who is vaccinated. Why more than one type of autoimmune disease occurs is explained by the fact that specific autoimmune T-cells have been shown to develop clones that attack multiple human tissues.
Burton A Waisbren
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Publication Detail:
Type:  Journal Article     Date:  2007-07-13
Journal Detail:
Title:  Medical hypotheses     Volume:  70     ISSN:  0306-9877     ISO Abbreviation:  Med. Hypotheses     Publication Date:  2008  
Date Detail:
Created Date:  2007-12-25     Completed Date:  2008-05-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  346-8     Citation Subset:  IM    
Waisbren Clinic, 2315 N. Lake Drive, Suite 815, Milwaukee, WI 53211, USA. <>
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MeSH Terms
Adjuvants, Immunologic / administration & dosage
Antigens, Viral
Autoimmune Diseases / etiology,  immunology
Demyelinating Diseases / etiology,  immunology
HLA Antigens
Hepatitis B Vaccines / adverse effects,  immunology
Herpesvirus 4, Human / immunology
Models, Immunological
Molecular Mimicry / immunology*
Viral Vaccines / administration & dosage,  adverse effects*
Reg. No./Substance:
0/Adjuvants, Immunologic; 0/Antigens, Viral; 0/HLA Antigens; 0/Hepatitis B Vaccines; 0/Viral Vaccines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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