Document Detail

Acquired amegakaryocytic thrombocytopenic purpura (AATP): a hospital based study.
MedLine Citation:
PMID:  10555427     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the frequency of Acquired Amegakaryocytic Thrombocytopenic Purpura (AATT), possible aetiology, course and prognosis. DESIGN: Retrospectively diagnosed patients, treated and followed prospectively. SETTING: Department of Haematology, Armed Forces Institute of Pathology, Rawalpindi. SUBJECTS: One hundred twenty patients with thrombocytopenic purpura. MAIN OUTCOME MEASURES: Response to treatment and course of disease. RESULTS: Out of 22 patients 2 died of cerebral haemorrhage, one transformed to Myelodysplastic Syndrome (MDS), one transformed to Acute Myeloid Levkaenia (AML). None is transfusion independent. CONCLUSION: AATT is not an infrequent disorder. It shows poor response to all available therapeutic modalities and has a potential for transformation into Myelodysplasia and acute myeloid leukaemia.
T Zafar; F Yasin; M Anwar; M Saleem
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  JPMA. The Journal of the Pakistan Medical Association     Volume:  49     ISSN:  0030-9982     ISO Abbreviation:  J Pak Med Assoc     Publication Date:  1999 May 
Date Detail:
Created Date:  1999-11-23     Completed Date:  1999-11-23     Revised Date:  2008-02-12    
Medline Journal Info:
Nlm Unique ID:  7501162     Medline TA:  J Pak Med Assoc     Country:  PAKISTAN    
Other Details:
Languages:  eng     Pagination:  114-7     Citation Subset:  IM    
Department of Haematology, Armed Forces Institute of Pathology, Rawalpindi.
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MeSH Terms
Megakaryocytes / pathology*
Middle Aged
Pakistan / epidemiology
Purpura, Thrombocytopenic* / diagnosis,  epidemiology,  etiology,  therapy
Retrospective Studies
Treatment Outcome

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