Document Detail


Acquired acute myelogenous leukemia after therapy for acute promyelocytic leukemia with t(15;17): a case report and review of the literature.
MedLine Citation:
PMID:  19530558     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Therapy-related myelodysplastic syndrome (t-MDS) and therapy-related acute myelogenous leukemia (t-AML) in patients with acute promyelocytic leukemia (APL) are rare events. The cumulative exposure to chemotherapy with alkylating agents and topoisomerase II inhibitors is associated with t-AML that may develop any time after the completion of the treatment. We report the case of an acquired AML who previously received therapy for APL, after two years of being diagnosed. The diagnosis was established by morphologic findings, membrane markers, cytogenetic studies, and fluorescence in situ hybridization (FISH). To our knowledge this is the first documented case in Puerto Rico of a patient with APL that developed a t-AML without the characteristic chromosomal and morphologic findings of APL.
Authors:
Rafael D Betancourt-García; Justiniano Castro; Adry C Fernández; Alberto López-Enríquez; Jean Fradera; Eileen Pacheco
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Puerto Rico health sciences journal     Volume:  28     ISSN:  0738-0658     ISO Abbreviation:  P R Health Sci J     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-06-17     Completed Date:  2009-07-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8303541     Medline TA:  P R Health Sci J     Country:  Puerto Rico    
Other Details:
Languages:  eng     Pagination:  146-50     Citation Subset:  IM    
Affiliation:
Hematology-Oncology Section, University District Hospital, UPR School of Medicine, San Juan, Puerto Rico.
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MeSH Terms
Descriptor/Qualifier:
6-Mercaptopurine / administration & dosage
Adult
Antineoplastic Agents, Alkylating / administration & dosage,  adverse effects
Antineoplastic Combined Chemotherapy Protocols / adverse effects,  therapeutic use
Chromosomes, Human, Pair 15 / ultrastructure
Chromosomes, Human, Pair 17 / ultrastructure
Chromosomes, Human, Pair 21 / ultrastructure
Chromosomes, Human, Pair 3 / ultrastructure
Chromosomes, Human, Pair 7
Cytarabine / administration & dosage
Daunorubicin / administration & dosage,  adverse effects
Drug Synergism
Fatal Outcome
Humans
Leukemia, Myeloid, Acute / drug therapy,  etiology*,  genetics
Leukemia, Promyelocytic, Acute / drug therapy*,  genetics
Male
Methotrexate / administration & dosage,  adverse effects
Mitoxantrone / administration & dosage,  adverse effects
Monosomy
Neoplasms, Second Primary / etiology*,  genetics
Translocation, Genetic*
Tretinoin / administration & dosage
Chemical
Reg. No./Substance:
0/Antineoplastic Agents, Alkylating; 147-94-4/Cytarabine; 20830-81-3/Daunorubicin; 302-79-4/Tretinoin; 50-44-2/6-Mercaptopurine; 59-05-2/Methotrexate; 65271-80-9/Mitoxantrone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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