Document Detail


Acquired hyperplastic gastric polyps after treatment of ulcer.
MedLine Citation:
PMID:  20708507     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND/PURPOSE: Healing of gastric ulcers requires repair by epithelial migration and proliferation. We have found a small proportion of patients with acquired hyperplastic polyps at the healed ulcer site. The aim of this study was to identify clinical characteristics that might be associated with the development of hyper-plastic polyps at the site of healed gastric ulcers. METHODS: This was a retrospective review of 86 patients with gastric ulcers from April 2006 to September 2008. After initial endoscopy, the patients were all treated with proton pomp inhibitors, after which a second endoscopy was performed. Demographic data, polyp characteristics (endoscopic and histological), Helicobacter pylori status, and duration of treatment were analyzed. RESULTS: A total of 24 hyperplastic gastric polyps were found in 18 patients; all at the site of the healed ulcer (20 in the antrum and 4 in the corpus). The mean size of the ulcers prior to treatment was 14.5 +/- 9.1 mm. Hyperplastic gastric polyps were more likely to occur at the site of ulcers larger than 10 mm (odds ratio = 9.57, 95% confidence interval =2.50-36.65). Age, sex, H. pylori status, ulcer location and duration of treatment did not differ significantly between patients with and without polyps. CONCLUSION: Hyperplastic polyps that develop after healing of gastric ulcers are likely to be extensive mucosal injury. A gastric ulcer larger than 10 mm is associated with a significantly increased risk of hyperplastic polyps.
Authors:
Wen-Hsiung Chang; Shou-Chuan Shih; Horng-Yuan Wang; Ching-Wei Chang; Chih-Jen Chen; Ming-Jen Chen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the Formosan Medical Association = Taiwan yi zhi     Volume:  109     ISSN:  0929-6646     ISO Abbreviation:  J. Formos. Med. Assoc.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-16     Completed Date:  2010-09-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9214933     Medline TA:  J Formos Med Assoc     Country:  China (Republic : 1949- )    
Other Details:
Languages:  eng     Pagination:  567-73     Citation Subset:  IM    
Copyright Information:
2010 Formosan Medical Association & Elsevier. Published by Elsevier B.V. All rights reserved.
Affiliation:
Division of Gastroenterology, Department of Internal Medicine, Mackay Memorial Hospital and Mackay Medicine, Nursing and Management College, Taipei, Taiwan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Anti-Ulcer Agents / therapeutic use
Biopsy
Endoscopy, Gastrointestinal
Female
Helicobacter Infections / complications,  drug therapy,  microbiology
Helicobacter pylori / drug effects
Humans
Hyperplasia / complications
Intestinal Polyps / etiology*,  pathology
Male
Proton Pump Inhibitors
Retrospective Studies
Stomach / pathology*
Stomach Ulcer / complications*,  drug therapy,  microbiology
Treatment Outcome
Chemical
Reg. No./Substance:
0/Anti-Ulcer Agents; 0/Proton Pump Inhibitors

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