| Acquired Hemophilia A in a Patient with Essential Thrombocythemia. | |
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MedLine Citation:
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PMID: 22301942 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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A 69-year-old woman with essential thrombocythemia (ET) developed giant ecchymosis, and she was admitted to hospital. Marked anemia (Hb 8.1 g/dl) accompanied by a prolonged activated partial thromboplastin time (89.6 s) was observed, and she received red blood cells (RBC) and fresh frozen plasma (FFP). On day 2 after admission, consciousness disturbance suddenly occurred, whereas computed tomography of the brain showed no evidence of bleeding. As the ecchymosis progressed, she developed shock. Although RBC and FFP transfusions were administered, she developed multi-organ failure and died 48 h after admission. Low factor VIII activity (<1%) accompanied by factor VIII inhibitor (17 Bethesda units) was found after her death. An autopsy revealed cerebral infarction without cerebral herniation. To date, acquired hemophilia A accompanying ET has been described in only one other patient. Although acquired factor VIII inhibitor is a rare disease, it should be tested for in ET patients with marked hemorrhagic tendency. |
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Authors:
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Naoki Mori; Kyoichi Totsuka; Noriko Ishimori; Kentaro Yoshinaga; Masanao Teramura; Sanshiro Noguchi; Hideaki Oda; Toshiko Motoji |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-01 |
Journal Detail:
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Title: Acta haematologica Volume: 127 ISSN: 1421-9662 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0141053 Medline TA: Acta Haematol Country: - |
Other Details:
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Languages: ENG Pagination: 170-172 Citation Subset: - |
Copyright Information:
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Copyright © 2012 S. Karger AG, Basel. |
Affiliation:
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Department of Hematology, Tokyo Women's Medical University, School of Medicine, Tokyo, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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