| Acquired Gitelman syndrome in a patient with primary Sjögren syndrome. | |
| | |
MedLine Citation:
|
PMID: 18805608 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Acquired Gitelman syndrome (GS) associated with Sjögren syndrome (SS) is rare, and the test to determine the pathophysiological state of acquired GS in patients with primary SS has not been reported previously. A 47-year-old woman with sicca complex presented to our clinic with intermittent muscle cramping and weakness involving both lower extremities over several months. Laboratory findings showed hypokalemic metabolic alkalosis, hypomagnesemia, and hypocalciuria, which met the criteria for GS. Diagnostic evaluation identified primary SS as the cause of the acquired GS. Light microscopic examination of renal tissue from the patient showed mild tubulointerstitial nephritis. Immunohistochemical staining of renal tissue showed the absence of the sodium-chloride cotransporter (NCCT) in the distal convoluted tubules. Incubation of the patient's serum with normal mouse kidney tissue showed a pattern of NCCT in the distal convoluted tubules similar to that of incubation of normal mouse kidney with the rabbit polyclonal anti-NCCT antibody. This is a rare case of acquired GS associated with primary SS, and our findings suggest the presence of circulating autoantibodies to NCCT. |
| | |
Authors:
|
Yong Kyun Kim; Ho Cheol Song; Wan-Young Kim; Hye Eun Yoon; Yeong-Jin Choi; Chang-Seok Ki; Cheol-Whee Park; Chul Woo Yang; Jin Kim; Yong-Soo Kim; Eui Jin Choi; Byung Kee Bang |
Related Documents
:
|
3631038 - Primary gastrointestinal kaposi's sarcoma in a patient with acquired immune deficiency ... 6671858 - Neuropsychiatric aspects of acquired immune deficiency syndrome. 1594228 - Cryptococcosis of the anterior segment in acquired immune deficiency syndrome. 18976358 - T-cell immunodeficiency in charge syndrome. 15950858 - Four different airway-management strategies in patient with launois-bensaude syndrome o... 6693368 - Epileptic kluver-bucy syndrome: case report. |
Publication Detail:
|
Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't Date: 2008-09-21 |
Journal Detail:
|
Title: American journal of kidney diseases : the official journal of the National Kidney Foundation Volume: 52 ISSN: 1523-6838 ISO Abbreviation: Am. J. Kidney Dis. Publication Date: 2008 Dec |
Date Detail:
|
Created Date: 2008-11-25 Completed Date: 2008-12-18 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8110075 Medline TA: Am J Kidney Dis Country: United States |
Other Details:
|
Languages: eng Pagination: 1163-7 Citation Subset: IM |
Affiliation:
|
Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seocho-Ku, Seoul, Korea. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Autoantibodies
/
blood Female Gitelman Syndrome / blood, complications*, pathology Humans Middle Aged Sjogren's Syndrome / blood, complications* |
| Chemical | |
Reg. No./Substance:
|
0/Autoantibodies |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Total fluorine, extractable organic fluorine, perfluorooctane sulfonate and other related fluorochem...
Next Document: Associations of dialysis modality and infectious mortality in incident dialysis patients in Australi...