| Acquired Fanconi Syndrome Associated With Prolonged Adefovir Dipivoxil Therapy in a Chronic Hepatitis B Patient. | |
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MedLine Citation:
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PMID: 21519215 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Adefovir dipivoxil (ADV) is one of the commonly used antiviral agents in the treatment of chronic hepatitis B infection. Nephrotoxicity is dose related and occurred at a daily dosage of >30 mg. However, it is now increasingly recognized that nephrotoxicity can occur at a daily dose of 10 mg. We present a case of acquired Fanconi syndrome in a patient with chronic hepatitis B who had been treated with ADV for 4 years. She presented with progressive muscle weakness and generalized bone pain. The laboratory results showed the feature of proximal renal tubule dysfunction, particularly severe hypophosphatemia. Diagnostic approach to hypophosphatemia and proximal renal tubular dysfunction is discussed. After switching over from ADV to entecavir, her symptoms and laboratory findings returned to normal. Acquired Fanconi syndrome can be associated with ADV at a conventional dosage, and therefore, patients treated with long-term ADV should have regular monitoring of renal function and calcium and phosphate levels. |
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Authors:
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Siu-Tong Law; Kin Kong Li; Yiu Yan Ho |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-23 |
Journal Detail:
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Title: American journal of therapeutics Volume: - ISSN: 1536-3686 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9441347 Medline TA: Am J Ther Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1Division of Gastroenterology and Hepatology, Department of Medicine and Geriatrics, Tuen Mun Hospital, Tuen Mun, Hong Kong; and 2Division of Endocrinology, Department of Medicine and Geriatrics, Tuen Mun Hospital, Tuen Mun, Hong Kong. |
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