| Acquired Factor VIII Inhibitor as Initial Manifestation of Collagen Vascular Disease: Response to Combination Immunosuppression as First-Line Therapy. | |
| | |
MedLine Citation:
|
PMID: 21412135 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Acquired hemophilia A is a rare disorder caused by the development of inhibitors to coagulation factor VIII. The case of a 74-year-old man who presented with spontaneous ecchymoses and was found to have acquired hemophilia A is reported. Bleeding was acutely controlled using recombinant activated factor VII. Combined modality immunosuppression was promptly initiated using intravenous methylprednisolone (later converted to oral prednisone), cyclophosphamide and rituximab. By day 17, inhibitor titer had decreased from 8.5 Bethesda units/mL to 1.3 units/mL and was subsequently undetectable; by day 26, factor VIII activity had increased from less than 1% to 42% and was greater than 100% by day 43. All treatment had concluded by day 40. Reported cases of the use of rituximab for acquired hemophilia in the elderly were reviewed. The use of rituximab as part of a combined immunosuppression regimen is an effective first-line approach to acquired hemophilia. |
| | |
Authors:
|
Bethany Wilson; Robert T Means |
Related Documents
:
|
3918835 - Osteoma cutis: computed tomography appearance. 11402285 - Metastatic calcification of the nasal septum presenting as an intraoral mass: a case re... 12913845 - Hyperplastic callus formation in osteogenesis imperfecta. 19853765 - Cystic lymphangioma of the breast in a 6-year-old boy. 16412105 - Impact of imported malaria on the burden of disease in northeastern venezuela. 1983885 - Eosinophilic granuloma of the cervical spine. a case report and review of the literature. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-3-15 |
Journal Detail:
|
Title: The American journal of the medical sciences Volume: - ISSN: 1538-2990 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-3-17 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0370506 Medline TA: Am J Med Sci Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
From the Department of Internal Medicine (bw, rtm), University of Kentucky College of Medicine, Lexington, Kentucky; and VA Medical Center (rtm), Lexington, Kentucky. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Electromyographic Assessment of Dexamethasone in Treatment of Post-Tonsillectomy Pain: Randomized, P...
Next Document: The Effect of Urinary Bladder Catheterization on Patient Care in an Internal Medicine Department.